1-Methylcyclopropane-1-sulfonyl chloride

Base Information

• Chemical Name: 1-Methylcyclopropane-1-sulfonyl chloride
• CAS No.: 923032-55-7
• Molecular Formula: C4H7ClO2S
• Molecular Weight: 154.617
• Hs Code.: 2902190000
• Mol file: 923032-55-7.mol

Synonyms:1-methyl-cyclopropanesulfonylchloride;1-methylcyclopropane-1-sulfonylchloride;Cyclopropanesulfonyl chloride,1-methyl;

Chemical Property of 1-Methylcyclopropane-1-sulfonyl chloride

Chemical Property:

• Boiling Point: 194.9±7.0 °C(Predicted)
• PSA: 42.52000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 2.18830

Purity/Quality:

98% ^*data from raw suppliers

1-Methylcyclopropane-1-sulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylcyclopropane-1-sulfonyl chloride

There total 1 articles about 1-Methylcyclopropane-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium 1-methylcyclopropane-1-sulfonate (923032-54-6) → 1-methylcyclopropane-1-sulfonyl chloride (923032-55-7)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 16h; Heating / reflux;

Reference yield: 94.0%

tert-butyl (3-amino-4-chlorophenyl)carbamate (885270-73-5) + 1-methylcyclopropane-1-sulfonyl chloride (923032-55-7) → tert-butyl (4-chloro-3-((1-methylcyclopropane)-1-sulfonamido)phenyl)carbamate

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield: 79.0%

1-methylcyclopropane-1-sulfonyl chloride (923032-55-7) + 3-nitro-aniline (99-09-2) → 1-methyl-N-(3-nitrophenyl)cyclopropane-1-sulfonamide

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

potassium 1-methylcyclopropane-1-sulfonate

Downstream raw materials:

1-methylcyclopropane-1-sulfonamide

Refernces

• 1、 -. "SUBSTITUTED IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TrkA) INHIBITORS". Paragraph 0639. . Retrieved 2016/01/15.
• 2、 -. "SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS". Page/Page column 65-66. . Retrieved 2013/07/05.