Cyclopropanesulfonamide, 1-methyl- (9CI)

Base Information

• Chemical Name: Cyclopropanesulfonamide, 1-methyl- (9CI)
• CAS No.: 669008-26-8
• Molecular Formula: C4H9NO2S
• Molecular Weight: 135.187
• Hs Code.: 2935009090
• Mol file: 669008-26-8.mol

Synonyms:Cyclopropanesulfonamide, 1-methyl- (9CI);1-methylcyclopropanesulfonamide;

Chemical Property of Cyclopropanesulfonamide, 1-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.027mmHg at 25°C
• Melting Point: 103-104 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.53
• Boiling Point: 246.4 °C at 760 mmHg
• PKA: 10.93±0.20(Predicted)
• Flash Point: 102.82 °C
• PSA: 68.54000
• Density: 1.348 g/cm³
• LogP: 1.60850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

1-Methylcyclopropane-1-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanesulfonamide, 1-methyl- (9CI)

There total 6 articles about Cyclopropanesulfonamide, 1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (1-methylcyclopropyl) sulfonylcarbamate (849022-29-3) → 1-methylcyclopropane-1-sulfonamide (669008-26-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield: 96.0%

N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide (669008-25-7) → 1-methylcyclopropane-1-sulfonamide (669008-26-8)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 16h;

DOI:10.1055/s-2006-933130

Reference yield: 96.0%

→ 1-methylcyclopropane-1-sulfonamide (669008-26-8)

Guidance literature:

upstream raw materials:

N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide

tert-butyl (1-methylcyclopropyl) sulfonylcarbamate

1-methylcyclopropane-1-sulfonyl chloride

C₉H₁₄F₂N₂O₃S*ClH

Downstream raw materials:

tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

Refernces

• 1、 -. "Hepatitis C virus inhibitors". Page/Page column 68; 69. . Retrieved 2017/05/31.
• 2、 Rudd, Michael T.,Butcher, John W.,Nguyen, Kevin T.,McIntyre, Charles J.,Romano, Joseph J.,Gilbert, Kevin F.,Bush, Kimberly J.,Liverton, Nigel J.,Holloway, M. Katharine,Harper, Steven,Ferrara, Marco,Difilippo, Marcello,Summa, Vincenzo,Swestock, John,Fritzen, Jeff,Carroll, Steven S.,Burlein, Christine,Dimuzio, Jillian M.,Gates, Adam,Graham, Donald J.,Huang, Qian,McClain, Stephanie,McHale, Carolyn,Stahlhut, Mark W.,Black, Stuart,Chase, Robert,Soriano, Aileen,Fandozzi, Christine M.,Taylor, Anne,Trainor, Nicole,Olsen, David B.,Coleman, Paul J.,Ludmerer, Steven W.,McCauley, John A.. "P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: Discovery of MK-2748 and MK-6325". supporting information. p. 727 - 735. Retrieved 2015/04/14.