(Intermediates of Rosuvastatin Calcium R-4

Base Information

• Chemical Name: (Intermediates of Rosuvastatin Calcium R-4
• CAS No.: 851440-19-2
• Molecular Formula: C₂₆H₃₄FN₃O₆S
• Molecular Weight: 535.637
• Mol file: 851440-19-2.mol

Synonyms:(Intermediates of Rosuvastatin Calcium R-4

Chemical Property of (Intermediates of Rosuvastatin Calcium R-4

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Intermediates of Rosuvastatin Calcium R-4

There total 20 articles about (Intermediates of Rosuvastatin Calcium R-4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester (289042-12-2,1378943-63-5) → 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester (851440-19-2)

Guidance literature:

With titanium(IV) isopropylate; In methanol; for 32h; Reflux;

Reference yield: 81.0%

C31H34FN3O4PS(1+)*Br(1-) + (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid methyl ester (164576-45-8) → 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester (851440-19-2)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃; stereoselective reaction;

Reference yield: 76.2%

C19H28FN3O2SSi + (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid methyl ester (164576-45-8) → 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester (851440-19-2)

Guidance literature:

With cesium fluoride; In dimethyl sulfoxide; at 20 - 92 ℃; for 5h;

upstream raw materials:

acetone

(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester

2-((4R,6S)-6-((benzo[d]thiazol-2-ylsulfonyl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid methyl ester

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Downstream raw materials:

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy-N-methylhept-6-enamide

Rosuvastatin lactone

(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester

rosuvastatin tetramethyl ammonium salt

Refernces

• 1、 -. "Synthesis of rosuvastatin intermediate synthesis process". Paragraph 0048; 0049. . Retrieved 2017/11/27.
• 2、 -. "Synthetic method for rosuvastatin methyl ester". . . Retrieved 2017/03/21.