rosuvastatin tetramethyl ammonium salt

Base Information

• Chemical Name: rosuvastatin tetramethyl ammonium salt
• CAS No.: 917805-79-9
• Molecular Formula: C₄H₁₂N*C₂₂H₂₇FN₃O₆S
• Molecular Weight: 554.683
• Mol file: 917805-79-9.mol

Synonyms:rosuvastatin tetramethyl ammonium salt

Chemical Property of rosuvastatin tetramethyl ammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of rosuvastatin tetramethyl ammonium salt

There total 2 articles about rosuvastatin tetramethyl ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester (851440-19-2) + tetramethyl ammoniumhydroxide (75-59-2,104422-11-9,123626-97-1,154636-59-6,195460-17-4,78017-87-5,93615-68-0,129654-61-1) → rosuvastatin tetramethyl ammonium salt (917805-79-9)

Guidance literature:

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester; With hydrogenchloride; In water; acetonitrile; at 25 ℃; for 18h;

tetramethyl ammoniumhydroxide; In tetrahydrofuran; ethyl acetate; at 20 - 50 ℃; for 4h;

Reference yield:

rosuvastatin tert-butyl ester (355806-00-7) + tetramethyl ammoniumhydroxide (75-59-2,104422-11-9,123626-97-1,154636-59-6,195460-17-4,78017-87-5,93615-68-0,129654-61-1) → rosuvastatin tetramethyl ammonium salt (917805-79-9)

Guidance literature:

With water; at 40 - 45 ℃; for 1h;

upstream raw materials:

rosuvastatin tert-butyl ester

tetramethyl ammoniumhydroxide

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid methyl ester

Refernces

• 1、 -. "PROCESS FOR PREPARING AMORPHOUS ROSUVASTATIN CALCIUM FREE OF IMPURITIES". Page/Page column 14-15. . Retrieved 2008/06/13.