(-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin

Base Information

• Chemical Name: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin
• CAS No.: 124919-00-2
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Mol file: 124919-00-2.mol

Synonyms:(-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin

Chemical Property of (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin

There total 20 articles about (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C17H21INOP (87214-08-2,87248-42-8) → (-)-(S)p Methyl methylphenylphosphinate (6389-79-3) + (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin (124919-00-2)

Guidance literature:

With sulfuric acid; In methanol; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(00)99124-X

Reference yield: 85.0%

pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) → (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin (124919-00-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine;

Reference yield: 85.0%

methanol (67-56-1) + C17H21INOP (87214-08-2,87248-42-8) → (-)-(S)p Methyl methylphenylphosphinate (6389-79-3) + (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin (124919-00-2)

Guidance literature:

With sulfuric acid; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(00)99124-X

upstream raw materials:

methanol

C₂₃H₂₅BrNOP

C₁₇H₂₁INOP

pseudoephedrine

Downstream raw materials:

N-((1S,2S)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

(+)-Chloroephedrine

Methamphetamin

Refernces

• 1、 Farndon, Joshua J.,Young, Tom A.,Bower, John F.. "Stereospecific Alkene Aziridination Using a Bifunctional Amino-Reagent: An Aza-Prilezhaev Reaction". supporting information. p. 17846 - 17850. Retrieved 2019/01/04.
• 2、 Cruz, Alejandro,Padilla-Martinez, Itzia Irene,Garcia-Baez, Efren V.. "An efficient synthesis of aziridines from ephedrines". experimental part. p. 909 - 913. Retrieved 2010/08/19.