2-(Hydroxyiminomethyl)-1-methylpyridinium iodide

Base Information

• Chemical Name: 2-(Hydroxyiminomethyl)-1-methylpyridinium iodide
• CAS No.: 94-63-3
• Molecular Formula: C₇H₉N₂O*I
• Molecular Weight: 264.066
• Hs Code.: 29333990
• ChEMBL ID: CHEMBL14577
• Mol file: 94-63-3.mol

Synonyms:CHEBI:32038;CHEMBL14577;HMS2230J10;HMS3373M15;FT-0613392;2-(hydroxyiminomethyl)-1-methylpyridinium iodide

Chemical Property of 2-(Hydroxyiminomethyl)-1-methylpyridinium iodide

Chemical Property:

• Melting Point: 220 ºC (dec.)
• PSA: 36.47000
• Density: 1.7439 (estimate)
• LogP: -2.67680
• Storage Temp.: 2-8°C
• Sensitive.: Light Sensitive
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 263.97596
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

99% ^*data from raw suppliers

2-Pyridinealdoxime methiodide 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36-24

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1=CC=CC=C1C=NO.[I-]

Technology Process of 2-(Hydroxyiminomethyl)-1-methylpyridinium iodide

There total 9 articles about 2-(Hydroxyiminomethyl)-1-methylpyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

2-pyridinealdoxime (873-69-8) + methyl iodide (74-88-4) → pralidoxime iodide (94-63-3,29603-75-6,74070-01-2)

Guidance literature:

In acetone; for 0.0666667h; Microwave irradiation;

DOI:10.5562/cca2937

Reference yield: 26.0%

N-methyl pyridinium 2-carboxaldehyde iodide salt (3784-97-2) → pralidoxime iodide (94-63-3,29603-75-6,74070-01-2)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 40h; Reflux;

DOI:10.3109/14756366.2015.1094468

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → pralidoxime iodide (94-63-3,29603-75-6,74070-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrobenzene

2: methanol / <-5

With methanol; nitrobenzene;

DOI:10.1021/ja01559a067

upstream raw materials:

(E)-pyridin-2-aldoxime

methyl iodide

N-methyl pyridinium 2-carboxaldehyde iodide salt

pyridine-2-carbaldehyde

Downstream raw materials:

ortho-N-Methylcyanopyridinium iodide

p-nitrophenolate

C₉H₁₁N₂O₂⁽¹⁺⁾*I^(1-)

Refernces

• 1、 Bu?i?, Valentina,Pavlovi?, Hrvoje,Roca, Sun?ica,Viki?-Topi?, Dra?en,Ga?o-Soka?, Dajana. "Microwave-assisted quaternization of various pyridine derivatives and their antibacterial activity". . p. 425 - 433. Retrieved 2018/01/26.
• 2、 Da Cunha Xavier Soares, Sibelle Feitosa,Vieira, Andréia Aguiar,Delfino, Reinaldo Teixeira,Figueroa-Villar, José Daniel. "NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes". . p. 5923 - 5930. Retrieved 2013/09/12.