C₃₆H₅₄F₂N₈O

Base Information Edit

Chemical Name:C₃₆H₅₄F₂N₈O
CAS No.:1519003-77-0
Molecular Formula:C₃₆H₅₄F₂N₈O
Molecular Weight:652.875
Hs Code.:
Mol file:1519003-77-0.mol

C<sub>36</sub>H<sub>54</sub>F<sub>2</sub>N<sub>8</sub>O

Synonyms:C₃₆H₅₄F₂N₈O

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Chemical Property of C₃₆H₅₄F₂N₈O Edit

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Technology Process of C₃₆H₅₄F₂N₈O

There total 14 articles about C₃₆H₅₄F₂N₈O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 376348-78-6
4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide

: 1519003-94-1
C₂₀H₃₅N₇*ClH

: 1519003-77-0
C₃₆H₅₄F₂N₈O

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml400370w

Reference yield:

: 76272-34-9
8-Benzyl-1αH,5αH-nortropan-3-one Oxime

: 1519003-77-0
C₃₆H₅₄F₂N₈O

Guidance literature:: Multi-step reaction with 13 steps

1: sodium; propan-1-ol / toluene / 12 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

7: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

8: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

9: hydrogen bromide / 2 h / 100 °C / Inert atmosphere

10: sodium hydroxide / water; dichloromethane / 20 °C / pH 12 / Inert atmosphere

11: sodium azide / ethanol / 4 h / 100 °C / Inert atmosphere

12: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

13: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; propan-1-ol; sodium azide; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400370w

Reference yield:

: 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine

: 1519003-77-0
C₃₆H₅₄F₂N₈O

Guidance literature:: Multi-step reaction with 12 steps

1: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

6: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

7: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

8: hydrogen bromide / 2 h / 100 °C / Inert atmosphere

9: sodium hydroxide / water; dichloromethane / 20 °C / pH 12 / Inert atmosphere

10: sodium azide / ethanol / 4 h / 100 °C / Inert atmosphere

11: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

12: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400370w