(S)-N-Methyl-1-(2-methoxyphenyl)propylamine

Base Information

• Chemical Name: (S)-N-Methyl-1-(2-methoxyphenyl)propylamine
• CAS No.: 128257-16-9
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.262
• Mol file: 128257-16-9.mol

Synonyms:(S)-N-Methyl-1-(2-methoxyphenyl)propylamine

Chemical Property of (S)-N-Methyl-1-(2-methoxyphenyl)propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-Methyl-1-(2-methoxyphenyl)propylamine

There total 3 articles about (S)-N-Methyl-1-(2-methoxyphenyl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide (128269-65-8) → (S)-N-Methyl-1-(2-methoxyphenyl)propylamine (128257-16-9) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene;

DOI:10.3987/COM-89-S35

Reference yield:

(3aS,6R)-6-(2-Methoxyphenyl)-5-oxa-7,8a-diazaperhydroazulen-8-one (128257-12-5) → (S)-N-Methyl-1-(2-methoxyphenyl)propylamine (128257-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / 3 h / 0 °C

2: 57 percent / Red-Al / toluene / 24 h / Ambient temperature

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1248/cpb.38.2627

Reference yield:

ortho-anisaldehyde (135-02-4) → (S)-N-Methyl-1-(2-methoxyphenyl)propylamine (128257-16-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / p-toluenesulfonic acid monohydrate / toluene / Heating

2: diethyl ether; tetrahydrofuran / 3 h / 0 °C

3: 57 percent / Red-Al / toluene / 24 h / Ambient temperature

With toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1248/cpb.38.2627

upstream raw materials:

(2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide

(3aS,6R)-6-(2-Methoxyphenyl)-5-oxa-7,8a-diazaperhydroazulen-8-one

ortho-anisaldehyde

Refernces

• 1、 Takahashi,Morimoto,Higashiyama. "Highly diastereoselective reaction of (3aS,o6R)-5-oxa-7, 8a-diazaperhydroazulen-8-ones with diethylzinc". . p. 2627 - 2631. Retrieved 2007/10/02.