Thiophene-2-ethylamine

Base Information

• Chemical Name: Thiophene-2-ethylamine
• CAS No.: 30433-91-1
• Molecular Formula: C6H9NS
• Molecular Weight: 127.21
• Hs Code.: 29339900
• European Community (EC) Number: 264-646-7,250-196-9
• DSSTox Substance ID: DTXSID60952773
• Nikkaji Number: J249.989D
• Wikidata: Q72508862
• ChEMBL ID: CHEMBL252803
• Mol file: 30433-91-1.mol

Synonyms:Thiophene-2-ethylamine;30433-91-1;2-Thiopheneethylamine;2-(thiophen-2-yl)ethanamine;Thiopheneethanamine;2-thien-2-ylethanamine;2-Thiopheneethanamine;2-(thiophen-2-yl)ethan-1-amine;2-(2-Thienyl)ethylamine;2-thiophen-2-ylethanamine;Thiopheneethylamine;2-(2-Aminoethyl)thiophene;64059-34-3;Thiophene-1-ethylamine;Thiopheneethanamine(9CI);MFCD00051495;EINECS 264-646-7;CHEMBL252803;2-(2-Thienyl)ethanamine;[2-(Thiophene-2-yl)ethyl]amine;EINECS 250-196-9;2-(THIOPHEN-2-YL)ETHYLAMINE;EC 250-196-9;2-(2'-thienyl)ethyl amine;thienylethylamine;2-thienylethlamine;Thiopene ethylamine;2-thienylethylamine;2-thiophenethylamine;2-aminoethylthiophene;2-thiophenyl ethylamine;2-thiophen-2-ylethylamine;2-(2-thienyl)ethyl amine;beta-(2-thienyl)ethylamine;.beta.-2-Thienylethylamine;2-(2-Thienyl)-ethylamine;2-thiophen-2-yl ethylamine;2-thiophen-2-yl-ethylamine;2-(2-aminoethyl)-thiophene;2-thiophene-2-yl-ethylamine;2-(2-Thienyl)ethanamine #;2-Thiopheneethylamine, 96%;BIDD:GT0488;SCHEMBL244450;2-(2-thienyl)-1-ethanamine;2-(thiophen-2-yl)ethaneamine;SCHEMBL7086137;SCHEMBL9221266;DTXSID60952773;HMS1789C01;STR06269;BBL001466;BDBM50227513;STK501234;AKOS000125051;AC-6275;CS-W016557;PB12982;PS-3264;SB10582;NCGC00330609-01;AM803664;SY004316;LS-153085;BB 0221013;FT-0602566;EN300-12163;AB01324885-02;W-106941;Z90662945;F2190-0537

Chemical Property of Thiophene-2-ethylamine

Chemical Property:

• Appearance/Colour: colorless to yellow liquid
• Vapor Pressure: 0.337mmHg at 25°C
• Melting Point: 202 °C
• Refractive Index: AUTOIGNITION
• Boiling Point: 199.7 °C at 760 mmHg
• PKA: 9.47±0.10(Predicted)
• Flash Point: 74.6 °C
• PSA: 54.26000
• Density: 1.102 g/cm³
• LogP: 1.94960
• Storage Temp.: Refrigerator (+4°C)
• Sensitive.: Air Sensitive
• Solubility.: DMSO, Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 127.04557046
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Aminoethyl)thiophene >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)CCN
• Uses: [2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90. 2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea.

Technology Process of Thiophene-2-ethylamine

There total 33 articles about Thiophene-2-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-azidoethyl)thiophene (149551-70-2) → [2-(2-thyenyl)ethyl]amine (30433-91-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield: 98.0%

2-cyanomethylthiophene (20893-30-5) → [2-(2-thyenyl)ethyl]amine (30433-91-1)

Guidance literature:

With indium(III) chloride; sodium tetrahydroborate; In tetrahydrofuran; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo201809a

Reference yield: 92.0%

2-(2-nitroethenyl)thiophene (874-84-0,34312-77-1) → [2-(2-thyenyl)ethyl]amine (30433-91-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Cooling with ice; Reflux;

upstream raw materials:

2-cyanomethylthiophene

2-(2-Bromoethyl)thiophene

3-(thiophen-2-yl)-propionamide

2-(2-nitroethenyl)thiophene

Downstream raw materials:

N-<2-(2-thienyl)ethyl>benzamide

1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

N-(2-(thien-2-yl)ethyl)formamide

2-chloro-N-(2-(thiophen-2-yl)ethyl)acetamide

Refernces

• 1、 Nguyen, Thuy,Gamage, Thomas F.,Decker, Ann M.,Finlay, David B.,Langston, Tiffany L.,Barrus, Daniel,Glass, Michelle,Harris, Danni L.,Zhang, Yanan. "Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids". . . Retrieved 2021/05/26.
• 2、 Sehajpal, Pallvi,Kirar, Seema,Ghosh, Saptarshi,Banerjee, Uttam Chand. "Generation of novel family of reductases from PCR based library for the synthesis of chiral alcohols and amines". . p. 83 - 91. Retrieved 2018/08/17.