N-[2-(2-Thienyl)ethyl]forMaMide

Base Information

• Chemical Name: N-[2-(2-Thienyl)ethyl]forMaMide
• CAS No.: 28783-49-5
• Molecular Formula: C₇H₉NOS
• Molecular Weight: 155.221
• Mol file: 28783-49-5.mol

Synonyms:

Chemical Property of N-[2-(2-Thienyl)ethyl]forMaMide

Chemical Property:

• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, DCM, Ethyl Acetate

Purity/Quality:

N-[2-(2-Thienyl)ethyl]formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-[2-(2-Thienyl)ethyl]formamide is a sulfur analog of Isoquinolines. N-[2-(2-Thienyl)ethyl]formamide have been used in attempts to prepare analogs of papaverine (P190500).

Technology Process of N-[2-(2-Thienyl)ethyl]forMaMide

There total 5 articles about N-[2-(2-Thienyl)ethyl]forMaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[2-(2-thyenyl)ethyl]amine (30433-91-1) + formic acid ethyl ester (109-94-4) → N-(2-(thien-2-yl)ethyl)formamide (28783-49-5)

Guidance literature:

With sodium hydrogencarbonate; at 20 ℃;

DOI:10.1016/j.bmc.2015.11.011

Reference yield: 83.5%

2-(2-thienyl)ethyl tosylate (40412-06-4) + formamide (77287-34-4,77287-35-5,60100-09-6) → N-(2-(thien-2-yl)ethyl)formamide (28783-49-5)

Guidance literature:

With formic acid; at 80 ℃; for 8.5h; Inert atmosphere;

Reference yield:

[2-(2-thyenyl)ethyl]amine (30433-91-1) + formic acid (64-18-6) → N-(2-(thien-2-yl)ethyl)formamide (28783-49-5)

Guidance literature:

With water; acetic anhydride; at 0 - 20 ℃; for 19h;

upstream raw materials:

[2-(2-thyenyl)ethyl]amine

formic acid ethyl ester

2-cyanomethylthiophene

formic acid

Downstream raw materials:

dihydro-6,7 thieno<3,2-c>pyridine

N-methyl-N-(2-(thien-2-yl)ethyl)amine

2-(thiophen-2-yl)ethyl isocyanide

Refernces

• 1、 -. "Synthesis method of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride". . . Retrieved 2017/09/02.
• 2、 Thompson, Mark J.,Chen, Beining. "Ugi reactions with ammonia offer rapid access to a wide range of 5-aminothiazole and oxazole derivatives". experimental part. p. 7084 - 7093. Retrieved 2010/01/06.