C₁₄H₁₈O₅

Base Information

• Chemical Name: C₁₄H₁₈O₅
• CAS No.: 1338825-57-2
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 1338825-57-2.mol

Synonyms:C₁₄H₁₈O₅

Chemical Property of C₁₄H₁₈O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₈O₅

There total 2 articles about C₁₄H₁₈O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-hydroxy-4-(methoxymethoxy)-3-methylphenyl]ethanone (942133-85-9) + Ethyl propionate (105-37-3,20741-13-3) → C14H18O5 (1338825-57-2)

Guidance literature:

1-[2-hydroxy-4-(methoxymethoxy)-3-methylphenyl]ethanone; Ethyl propionate; With sodium hydride; In tetrahydrofuran; mineral oil; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; mineral oil; pH=8; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.07.051

Reference yield:

1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1) → C14H18O5 (1338825-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 1.5 h / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / Inert atmosphere; Reflux

2.2: pH 8 / Inert atmosphere

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone; mineral oil;

DOI:10.1016/j.ejmech.2011.07.051

Reference yield:

C14H18O5 (1338825-57-2) → 3-((2-ethyl-8-(hydroxymethyl)-4-oxo-4H-chromen-7-yloxy)methyl)benzonitrile (1338825-88-9)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride; water / ethanol / 0.75 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice

3: N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4: acetic anhydride / 2 h / Reflux

5: hydrogenchloride; water / ethanol / 2 h / Reflux

6: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; water; acetic anhydride; potassium carbonate; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.07.051

upstream raw materials:

1-[2-hydroxy-4-(methoxymethoxy)-3-methylphenyl]ethanone

Ethyl propionate

1-(2,4-dihydroxy-3-methylphenyl)ethanone

Downstream raw materials:

7-ethoxy-2-ethyl-8-((4-(2-oxo-2-phenylacetyl)piperazin-1-yl)methyl)-4H-chromen-4-one

7-ethoxy-2-ethyl-8-((4-(2-oxo-3-phenylpropanoyl)piperazin-1-yl)methyl)-4H-chromen-4-one

2-ethyl-8-(hydroxymethyl)-7-(3-(trifluoromethyl)benzyloxy)-4H-chromen-4-one

3-((2-ethyl-8-(hydroxymethyl)-4-oxo-4H-chromen-7-yloxy)methyl)benzonitrile

Refernces

• 1、 Chen, Ying,Cheng, Ming,Liu, Fa-Qiang,Xia, Peng,Qian, Keduo,Yu, Donglei,Xia, Yi,Yang, Zheng-Yu,Chen, Chin-Ho,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung. "Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2′,3′-seco-3′-nor DCP and DCK analogues". experimental part. p. 4924 - 4936. Retrieved 2011/11/29.