9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione

Base Information Edit

Chemical Name:9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione
CAS No.:37413-99-3
Molecular Formula:C22H28 O4
Molecular Weight:356.462
Hs Code.:
Mol file:37413-99-3.mol

Synonyms:9,11b-Epoxy-17-hydroxy-16b-methyl-9b-pregna-1,4-diene-3,20-dione

Suppliers and Price of 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
9β,11β-Epoxy-21dehydroxyBetamethasone
50mg
$ 165.00

Total 2 raw suppliers

Chemical Property of 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione Edit

Chemical Property:

PSA：66.90000
LogP:2.99170

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

9β,11β-Epoxy-21dehydroxyBetamethasone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 9β,11β-Epoxy-21dehydroxy betamethasone is synthesized from 9β,11β-epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (E589175), which is a metabolite of momestasone furoate (M490000).

Technology Process of 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione

There total 10 articles about 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

: 14135-32-1
16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione

: 37413-99-3
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione

Guidance literature:: 16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione; With perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In N,N-dimethyl-formamide; for 3h; cooling;

With sodium hydroxide; In methanol; dichloromethane; water; for 2h; cooling;
DOI:10.1080/00397910500464855

Reference yield:

: 884488-47-5
16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one

: 37413-99-3
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / pyridine / 20 °C

2.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH₂Cl₂ / 20 h / 20 °C

3.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C

4.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating

4.2: 50 percent / p-toluenesulfonic acid / CH₂Cl₂ / 4 h / 20 °C

5.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling

5.2: 75.8 percent / sodium hydroxide / CH₂Cl₂; methanol; H₂O / 2 h / cooling

With pyridine; perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 3-iodosylbenzoic acid; diphenyl diselenide; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1080/00397910500464855

Reference yield:

: 884488-49-7
16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene

: 37413-99-3
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating

1.2: 50 percent / p-toluenesulfonic acid / CH₂Cl₂ / 4 h / 20 °C

2.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling

2.2: 75.8 percent / sodium hydroxide / CH₂Cl₂; methanol; H₂O / 2 h / cooling

With perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 3-iodosylbenzoic acid; diphenyl diselenide; In N,N-dimethyl-formamide; toluene;
DOI:10.1080/00397910500464855