(+)-KETAMINE

Base Information

• Chemical Name: (+)-KETAMINE
• CAS No.: 33643-47-9
• Molecular Formula: C13H16 Cl N O . Cl H
• Molecular Weight: 274.19
• Hs Code.: 2922399090
• Mol file: 33643-47-9.mol

Synonyms:Cyclohexanone,2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (2S)- (9CI); Cyclohexanone,2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (S)-; Cyclohexanone,2-(o-chlorophenyl)-2-(methylamino)-, hydrochloride, (-)- (8CI);(+)-(S)-Ketamine hydrochloride; (S)-(+)-Ketamine hydrochloride;(S)-(-)-Ketamine hydrochloride; Ketanest S

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (+)-KETAMINE

Chemical Property:

• PSA: 29.10000
• LogP: 3.28870
• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: (S)-Ketamine (hydrochloride) (Item No. 9001961) is an analytical reference material categorized as an arylcyclohexylamine. Ketamine is a dissociative anesthetic that has been abused recreationally. (S)-Ketamine (hydrochloride) is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

Technology Process of (+)-KETAMINE

There total 14 articles about (+)-KETAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

(S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone tartrate → (-)-Ketamine hydrochloride (33643-47-9)

Guidance literature:

With sodium hydroxide; In water; acetone; at 65 ℃; for 1h;

DOI:10.1021/acs.joc.0c01090

Reference yield: 79.0%

(S)-ketamine (100477-72-3,33643-46-8,33643-49-1) → (-)-Ketamine hydrochloride (33643-47-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/acs.oprd.9b00553

Reference yield: 41.0%

L-Tartaric acid (87-69-4,138508-61-9) + ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1) → (+)-Ketamine hydrochloride (33795-24-3) + (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone tartrate + (-)-Ketamine hydrochloride (33643-47-9)

Guidance literature:

L-Tartaric acid; ketamine; In water; acetone; for 0.5h; Reflux;

With sodium hydroxide; In water;

With hydrogenchloride; In ethyl acetate;

DOI:10.1021/acs.oprd.9b00436

upstream raw materials:

(R)-1-(2-chlorophenyl)-2-ethylidene-1-methylaminocyclohexane

(+/-)-ketamine hydrochloride

(S)-ketamine

L-Tartaric acid

Downstream raw materials:

(S)-ketamine

Refernces

• 1、 -. "Racemization method of ketamine and derivative or salt thereof". Paragraph 0080-0104; 0117-0122. . Retrieved 2021/02/20.
• 2、 Gao, Shenghua,Gao, Xuezhi,Yang, Zhezhou,Zhang, Fuli. "Process Research and Impurity Control Strategy of Esketamine". . p. 555 - 566. Retrieved 2020/05/19.