(S)-4-Carbamoyl-3-phenyl-butyric acid

Base Information

• Chemical Name: (S)-4-Carbamoyl-3-phenyl-butyric acid
• CAS No.: 446062-61-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 446062-61-9.mol

Synonyms:(S)-4-Carbamoyl-3-phenyl-butyric acid

Chemical Property of (S)-4-Carbamoyl-3-phenyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-Carbamoyl-3-phenyl-butyric acid

There total 4 articles about (S)-4-Carbamoyl-3-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenylpentandiamid (78533-83-2) → C11H13NO3 + (S)-4-Carbamoyl-3-phenyl-butyric acid (446062-61-9)

Guidance literature:

With Rhodococcus erythropolis AJ₂₇₀ cells; In aq. phosphate buffer; at 30 ℃; pH=7; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/adsc.201800956

Reference yield:

3-phenylglutaronitrile (78533-73-0) → (S)-4-Carbamoyl-3-phenyl-butyric acid (446062-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Rhodococcus sp. AJ₂₇₀ cells / aq. phosphate buffer; acetone / 24 h / 30 °C / pH 7.0

2: 164 mg / 30 percent H₂O₂; NaOH / H₂O

With sodium hydroxide; Rhodococcus sp. AJ₂₇₀ cells; dihydrogen peroxide; In phosphate buffer; water; acetone;

DOI:10.1016/S0957-4166(02)00028-9

Reference yield:

3-phenylglutaronitrile (78533-73-0) → C11H13NO3 + (S)-4-Carbamoyl-3-phenyl-butyric acid (446062-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; dihydrogen peroxide / methanol; dimethyl sulfoxide; water / 0 °C

2: Rhodococcus erythropolis AJ₂₇₀ cells / aq. phosphate buffer / 30 °C / pH 7 / Enzymatic reaction

With dihydrogen peroxide; potassium carbonate; In methanol; aq. phosphate buffer; water; dimethyl sulfoxide;

DOI:10.1002/adsc.201800956

upstream raw materials:

3-phenylglutaronitrile

3-Phenylpentandiamid

benzaldehyde

Downstream raw materials:

(S)-Phenibut

Refernces

• 1、 Wang, Mei-Xiang,Liu, Chu-Sheng,Li, Ji-Sheng. "Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids". . p. 3367 - 3373. Retrieved 2007/10/03.