1094172-73-2Relevant articles and documents
Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate
Oikawa, Masato,Ikoma, Minoru,Sasaki, Makoto
, p. 4654 - 4666 (2011/10/03)
We report herein the approach to the key advanced intermediate in the synthesis of the bioactive marine natural product dragmacidin D. By employing a modular synthesis strategy of three fragments (5, 7, and 8), the advanced intermediate 3 has been successfully synthesized in 2.5% yield over 15 steps by starting from nitrotoluene 20. The synthesis also involves sequential cross-coupling reactions, namely Sonogashira and Suzuki-Miyaura reactions, so that various analogues can be efficiently synthesized, which will allow the study of structure-activity relationships of dragmacidin D.