124919-00-2

Basic information

• Product Name: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin
• Synonyms: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin
• CAS NO: 124919-00-2
• Molecular Weight: 147.22
• Mol File: 124919-00-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin(CAS DataBase Reference)
• NIST Chemistry Reference: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin(124919-00-2)
• EPA Substance Registry System: (-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin(124919-00-2)

Safety Data

• Hazardous Substances Data: 124919-00-2(Hazardous Substances Data)

Upstream product

• 87214-08-2 C₁₇H₂₁INOP 
• 299-42-3 ephedrine 
• 64-17-5 ethanol 
• 94133-42-3 (+)-Chloroephedine hydrochloride 
• 873-66-5 1-propenylbenzene 
• 87214-07-1 (4S,5R)-3,4-Dimethyl-2,5-diphenyl-[1,3,2]oxazaphospholidine 
• 116432-33-8 (+)-(2R,3S)-3,4-dimethyl-2,5-diphenyl-nitrobenzo<4,3-g>1,6-dioxa-4-aza-5-phospha (5-PV) spiro <4.4>nonane 
• 50-98-6 ephedrine hydrochloride 
• 100-39-0 benzyl bromide 
• 90-82-4 pseudoephedrine 
• 67-56-1 methanol 
• 87214-10-6 C₂₃H₂₅BrNOP 

Downstream Products

• 29724-89-8 N-((1S,2S)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide 
• 25394-33-6 (+)-Chloroephedrine 
• 537-46-2 Methamphetamin 
• 908343-65-7 (4S,5R)-cis-3-methylamino-4-methyl-5-phenylthiazolidine-2-thione 

Relevant articles and documents

Experimental and theoretical investigations for the regio and stereoselective transformation of trans 1,2,3-trisubstituted aziridines into trans oxazolidin-2-ones

The regio and stereoselective transformation of trans 1,2,3-trisubstituted aziridines into trans oxazolidin-2-ones takes place in good yield. However, the cis configuration at C2 and C3 in monocyclic aziridines is a limiting factor for this transformation

Efficient synthesis of cis-thiazolidinethiones derived from ephedrines

The reaction of chlorodeoxypseudoephedrine or chlorodeoxynorpseudoephedrine hydrochlorides with sodium dithiocarbonate in stirring ethanol at 0 °C to stereoselectively afford the corresponding cis-thiazolidinethiones in good yields (81% and 95%) is reported. The in situ formation of a cis-aziridine to explain the presence of trans-thiazolidinethione as a side product is proposed when the same reaction was carried out at room temperature. In addition, a 70:30 mixture of trans-isomers of a thiazolidinethione/isothiazolidinethione was formed when a cis-aziridine NH was reacted with carbon disulfide in refluxing ethanol. The analogous reaction with cis-aziridine N-Me stereoselectively affords the corresponding cis-thiazolidinethione. The 1H and 13C NMR data of the thiazolidinethiones were assigned. cis-3,4-Dimethyl-5-phenylthiazolidine-2-thione was crystallized from ethanol and its X-ray diffraction structure was analyzed.

Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands

A chiral ligand having the following structure: STR1 wherein AR is any aromatic and/or ring structure, and R is selected from the group consisting of aryl, oxygenated aryl, alkyl, oxygenated alkyl, AR, oxygenated AR and combinations thereof.