129075-49-6Relevant articles and documents
Synthesis of 3,4-dihydro-5-[11C]methoxy-1(2H)-isoquinolinone as a Potential Tracer for Poly(ADP-ribose) Synthetase
Miyake, Yoshinori,Shimadzu, Hiroshi,Hashimoto, Naoto,Ishida, Yoshio,Shibakawa, Masahiko,Nishimura, Tsunehiko
, p. 983 - 988 (2000)
Synthesis of 3,4-dihydro-5-[11C]methoxy-1(2H)-isoquinolinone ([11C]MIQO), a potent poly (ADP-ribose) synthetase inhibitor, was devised in order to evaluate whether it is possible to image excessive activation of poly(ADP-ribose) synthetase (PARS) by positron emission tomography. [11C]MIQO was prepared by O-[11C]methylation of 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone, obtained by a Schmidt reaction with 4-hydroxy-1-indanone, sodium azide and trichloroacetic acid, with [11C]methyl triflate. Total synthesis time from EOB was 35 minutes. The radiochemical yield based on [11C]carbon dioxide was 31 +/- 8 percent (n=8; decay corrected). The final product had a specific activity of 76 GBq/umol at EOS, and the radiochemical purity of [11C]MIQO was over 99 percent.
17a-HYDROXYLASE/C17,20-LYASE INHIBITORS
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Paragraph 0355, (2014/03/21)
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
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Page/Page column 60, (2012/04/04)
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.