13336-31-7

Basic information

• Product Name: 4-METHOXY-1-INDANONE
• Synonyms: 4-METHOXY-1-INDANONE;4-METHOXY-INDAN-1-ONE;4-METHOXY-1-INDANONE 99%;4-Methoxyindanone;4-Methoxy-2,3-dihydro-1H-inden-1-one;2,3-Dihydro-4-methoxy-1H-inden-1-one;4-Methoxy-2,3-dihydroinden-1-one;1H-Inden-1-one, 2,3-dihydro-4-Methoxy-
• CAS NO: 13336-31-7
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• Product Categories: Indane/Indanone and Derivatives;Heterocycles series;indanone;C10;Carbonyl Compounds;Ketones
• Mol File: 13336-31-7.mol
• Article Data: 30

Chemical Properties

• Melting Point: 105-107 °C (dec.)(lit.)
• Boiling Point: 115-120 °C0.5 mm Hg(lit.)
• Flash Point: 145.373 °C
• Appearance: white to light yellow crystal powder
• Density: 1.0281 (rough estimate)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-METHOXY-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-1-INDANONE(13336-31-7)
• EPA Substance Registry System: 4-METHOXY-1-INDANONE(13336-31-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13336-31-7(Hazardous Substances Data)

Usage

Description

4-Methoxy-1-indanone is a benzo-fused ketone and a 1-indanone derivative, characterized by its white to light yellow crystal powder appearance. It is synthesized and has been reported in the literature.

Uses

Used in Comparative Studies:
4-Methoxy-1-indanone is used as a comparative study agent for analyzing the effect of different substituents on the reaction kinetics of various benzo-fused ketones, specifically through the biocatalysed oxidation reaction.
Used in Synthesis of Isomeric Mixtures:
It serves as a starting material in the synthesis of isomeric mixtures of oximes, contributing to the development of diverse chemical compounds.
Used in Organic Chemistry Research:
4-Methoxy-1-indanone is utilized as a starting material in the synthesis of benzo-fused indolizidine and 4-methoxy-1-indanyl compounds, which are significant in organic chemistry research.
Used in Nitration Reactions:
4-METHOXY-1-INDANONE is employed in the synthesis of 4-methoxy-5-nitro-1-indanone through nitration reactions, expanding the range of chemical derivatives available for further study and application.
Used in Pharmaceutical Chemistry:
As one of the reactants, 4-Methoxy-1-indanone is involved in the synthesis of E-2-chloro-8-methyl-3-[(4′-methoxy-1′-indanoyl)-2′-methyliden]-quinoline (IQ), a quinoline derivative with potential applications in pharmaceutical chemistry.

InChI:InChI=1/C10H10O2/c1-12-10-4-2-3-7-8(10)5-6-9(7)11/h2-4H,5-6H2,1H3

Upstream product

• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 59725-59-6 3-<2-(benzyloxy)phenyl>propionic acid 
• 67199-57-9 4-methoxy-2,3-dihydro-1H-inden-1-ol 
• 67-56-1 methanol 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 59725-62-1 Benzoic acid 2-(2-chlorocarbonyl-ethyl)-phenyl ester 
• 59725-61-0 4-(benzyloxy)-1-indanone 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 

Downstream Products

• 99545-62-7 4-methoxy-2,2-dimethylindan-1-one 
• 62-53-3 aniline 
• 1116359-18-2 4-methoxy-5-nitro-2,3-dihydro-1H-inden-1-one 
• 157989-07-6 4-methoxy-7-nitro-1-indanone 
• 129075-49-6 3,4-dihydro-5-methoxy-1(2H)-isoquinolinone 
• 1419386-60-9 C₃₄H₃₇F₅N₄O₆S 
• 1419386-62-1 C₃₉H₄₉BF₂N₄O₅ 
• 1419384-78-3 C₄₇H₅₈F₂N₈O₆ 
• 1419384-89-6 C₅₂H₆₂N₈O₆ 
• 1419387-66-8 C₂₃H₂₄O₂ 
• 1419387-69-1 C₂₃H₂₂Br₂O₂ 
• 1419387-72-6 C₄₃H₅₄N₂O₁₀ 
• 1419387-74-8 C₄₃H₅₄N₆O₄ 
• 1419384-91-0 C₄₇H₆₀N₈O₆ 

Relevant articles and documents

Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents

5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.

Methoxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A AR antagonists for the potential treatment of neurological conditions

A prior study reported on hydroxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A antagonists for the potential treatment of neurological conditions. A lead compound (1a) was identified with both A1 and A

Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease

A series of pyridine-linked indanone derivatives were designed and synthesized to discover new small molecules for the treatment of inflammatory bowel disease (IBD). Compounds 5b and 5d exhibited strongest inhibitory activity against TNF-α-induced monocyte adhesion to colon epithelial cells (an in vitro model of colitis). In TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced rat colitis model, oral administration of the compounds 5b and 5d ameliorated colitis with significant recovery in altered expressions of E-cadherin, TNF-α and IL-1β expressions, indicating 5b and 5d as potential agents for therapeutics development against IBD.