13327-27-0 Usage
Description
6-Methylpyridazin-3(2H)-one is a heterocyclic organic compound with a pyridazinone core and a methyl group attached to the 6th position. It is a versatile chemical intermediate and has potential applications in various industries due to its unique chemical properties.
Uses
Used in Textile Industry:
6-Methylpyridazin-3(2H)-one is used as a lignin-based dye for wool, providing coloration and enhancing the appearance of the textile material.
Used in Pharmaceutical Industry:
6-Methylpyridazin-3(2H)-one is used as a reactant for the synthesis of C-(1-aryl-cyclohexyl)-methylamine derivatives, which are selective, orally available inhibitors of dipeptidyl peptidase IV. These inhibitors play a crucial role in the treatment of type 2 diabetes by regulating glucose levels.
6-Methylpyridazin-3(2H)-one is also used in the synthesis of imidazopyridazinone derivatives, which act as PDE7 inhibitors. These inhibitors have potential applications in the treatment of inflammatory and autoimmune diseases by modulating the immune response.
Furthermore, 6-Methylpyridazin-3(2H)-one is used in the development of pyridazinone derivatives with an arylpiperazinylalkyl chain, which are potent, orally active, antinociceptive agents. These agents have potential applications in the management of pain and inflammation by targeting specific receptors and pathways in the body.
Synthesis Reference(s)
Synthesis, p. 1158, 1994 DOI: 10.1055/s-1994-25663
Check Digit Verification of cas no
The CAS Registry Mumber 13327-27-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,3,2 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13327-27:
(7*1)+(6*3)+(5*3)+(4*2)+(3*7)+(2*2)+(1*7)=80
80 % 10 = 0
So 13327-27-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O/c1-4-2-3-5(8)7-6-4/h2-3H,1H3,(H,7,8)
13327-27-0Relevant articles and documents
VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS
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Paragraph 0134; 0135, (2018/06/23)
FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists
Giovannoni, Maria Paola,Schepetkin, Igor A.,Cilibrizzi, Agostino,Crocetti, Letizia,Khlebnikov, Andrei I.,Dahlgren, Claes,Graziano, Alessia,Dal Piaz, Vittorio,Kirpotina, Liliya N.,Zerbinati, Serena,Vergelli, Claudia,Quinn, Mark T.
, p. 512 - 528 (2013/07/27)
Formyl peptide receptors (FPRs) play an essential role in the regulation of endogenous inflammation and immunity. In the present studies, a large series of pyridazin-3(2H)-one derivatives bearing an arylacetamide chain at position 2 was synthesized and te
Synthesis of substituted pyridines and pyridazines via ring closing metathesis
Donohoe, Timothy J.,Fishlock, Lisa P.,Basutto, Jose A.,Bower, John F.,Procopiou, Panayiotis A.,Thompson, Amber L.
supporting information; experimental part, p. 3008 - 3010 (2009/12/01)
RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system. The Royal Society of Chemistry 2009.