134107-65-6

Basic information

• Product Name: [S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one
• Synonyms: [S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one;(7aS)-3-Phenyl-1,7a-dihydropyrrolo[1,2-c]oxazol-5(3H)-one ;(3R,7aS)-1,7a-Dihydro-3-phenyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one;3-Phenyl-1,7a-dihydropyrrolo[1,2-c]oxazol-5(3H)-one
• CAS NO: 134107-65-6
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22124
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 134107-65-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 424.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, Ether, Ethyl Acetate
• PKA: -2.06±0.40(Predicted)
• CAS DataBase Reference: [S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: [S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one(134107-65-6)
• EPA Substance Registry System: [S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one(134107-65-6)

Safety Data

• Hazardous Substances Data: 134107-65-6(Hazardous Substances Data)

Usage

Description

[S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one is a chiral organic compound characterized by its unique molecular structure and yellow solid appearance. It is a key intermediate in the synthesis of pharmaceutical compounds, particularly Boceprevir and its analogs.

Uses

Used in Pharmaceutical Industry:
[S]-3-Phenyl-1,7a-dihydro-pyrrolo[1,2-c]oxazol-5-one is used as a key intermediate in the synthesis of Boceprevir (B674500) and its analogs for the treatment of hepatitis C virus (HCV) infections. Its chiral nature and unique structure play a crucial role in the development of these therapeutic agents, contributing to their efficacy and selectivity in targeting the viral protease enzyme.

Upstream product

• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 100-52-7 benzaldehyde 
• 17342-08-4 (S)-Pyroglutaminol 
• 56-86-0 L-glutamic acid 
• 34837-55-3 Phenylselenyl bromide 
• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 

Downstream Products

• 154495-19-9 (1aS,1bR,4R,5aS)-4-Phenyl-tetrahydro-1,3-dioxa-4a-aza-cyclopropa[a]pentalen-5-one 
• 154631-82-0 (2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one 
• 515863-19-1 (3R,7S,7aS)-7-Amino-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 597569-37-4 (1R,3aS,3bS,6aR)-5-methyl-1-phenyl-3a,3b,6,6a-tetrahydro-3H-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one 
• 597569-36-3 (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one 
• 216481-23-1 (2S,3S)-1-benzyl-3-(N-benzylamino)-2-hydroxymethylpyrrolidine 
• 118758-48-8 (2S,3R)-3-phenyl-pyrrolidine-2-carboxylic acid 
• 123724-21-0 (2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 1108172-95-7 tert-butyl (1S,2S,5R)-2-(aminomethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 

Relevant articles and documents

BACTERIAL EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula I: (formula I) and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST

The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in fomulas (I) or a pharmaceutically acceptable salt thereof.

Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors

Abstract Herein we have reported design, synthesis and in vitro biological evaluation of a library of bicyclic lactams that led to the discovery of compounds 6 and 7 as a novel class of α-glucosidase inhibitors. They inhibited α-glucosidase (yeast origin)