597569-36-3

Basic information

• Product Name: (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one
• Synonyms: (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one
• CAS NO: 597569-36-3
• Molecular Weight: 255.316
• Mol File: 597569-36-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one(597569-36-3)
• EPA Substance Registry System: (1R,3aS,3bS,6aR)-5-Methylene-1-phenyl-hexahydro-2-oxa-7a-aza-cyclopenta[a]pentalen-7-one(597569-36-3)

Safety Data

• Hazardous Substances Data: 597569-36-3(Hazardous Substances Data)

Upstream product

• 72047-94-0 [2-(acetoxymethyl)prop-2-enyl]trimethylsilane 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 

Downstream Products

• 597569-39-6 C₁₇H₁₉NO₂ 

Relevant articles and documents

[3+2] Cycloaddition of trimethylenemethane (TMM) to α,β-unsaturated γ-lactam. Preparation of 5,5-fused proline surrogates

Unsaturated lactam derived from (S)-pyroglutaminol undergoes a totally stereoselective cycloaddition reaction with (2-(acetoxymethyl)-3-allyl)trimethylsilane in the presence of Pd(P(OiPr)3)4 in refluxing toluene. This step was efficiently used to introduced the 5,5-fused framework desired for the preparation of novel proline surrogates.