135286-01-0

Basic information

• Product Name: 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL
• Synonyms: 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL
• CAS NO: 135286-01-0
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 0
• Mol File: 135286-01-0.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL(135286-01-0)
• EPA Substance Registry System: 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL(135286-01-0)

Safety Data

• Hazardous Substances Data: 135286-01-0(Hazardous Substances Data)

Usage

Description

2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL is a chemical compound characterized by the molecular formula C17H23NO. It is a derivative of piperidine, featuring a phenyl and an ethanol moiety attached to the piperidine ring. 2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL is under investigation for its potential pharmaceutical applications, particularly for its analgesic and sedative effects, and may also have implications as a psychoactive substance due to its influence on the central nervous system. Further research is essential to elucidate its full pharmacological profile and possible medical uses.

Uses

Used in Pharmaceutical Industry:
2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL is used as a potential analgesic for its pain-relieving properties, offering a new avenue for the development of medications to treat various types of pain.
2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL is used as a potential sedative for its calming effects, which could be beneficial in the management of anxiety and sleep disorders.
Used in Psychopharmacology Research:
2-PHENYL-2-PIPERIDIN-1-YL-ETHANOL is used as a subject of study in psychopharmacology to explore its effects on the central nervous system, with the aim of understanding its potential as a psychoactive drug and its implications for mental health treatment.

Upstream product

• 96-09-3 styrene oxide 
• 23535-28-6 methyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 110-89-4 piperidine 
• 1074-30-2 (piperidinyl)trimethylstannane 
• 7550-06-3 ethyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 110-86-1 pyridine 
• 108-91-8 cyclohexylamine 
• 100-42-5 styrene 
• 111-24-0 1,5-dibromo-pentane 
• 20989-17-7 (2S)-2-phenylglycinol 
• 20780-53-4 (R)-Styrene oxide 
• 154472-05-6 (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol 
• 2935-35-5 (S)-2-phenylglycine 

Downstream Products

• 189077-97-2 Thioacetic acid S-((R)-1-phenyl-2-piperidin-1-yl-ethyl) ester 
• 934374-29-5 C₁₄H₂₁NO₃S 
• 934374-28-4 Methanesulfonic acid (R)-1-phenyl-2-piperidin-1-yl-ethyl ester 

Relevant articles and documents

In Situ Conformational Fixation of the Amide Bond Enables General Access to Medium-Sized Lactams via Ring-Closing Metathesis

In this work, a novel phenethylamine-derived protecting group is introduced, which is able to significantly enhance the Grubbs I-catalyzed formation of 9- to 12-membered lactams through charge-induced conformational fixation under acidic conditions. As the new approach is particularly valuable for 10- and 11-membered ring systems, for which no related precedence was available so far, the overall strategy now offers general access to medium-sized lactams via ring closing metathesis. Cleavage of the protecting group can be achieved through a mild sequence combining N-oxidation and Cope elimination or alternatively under standard hydrogenation conditions.

Regiospecific Conversion of Oxiranes into Primary Alcohols via Reaction with Organotin Derivatives

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C-H Functionalization of Amino Alcohols by Osmium Tetroxide/NMO or TPAP/NMO: Protecting Group-Free Synthesis of Indolizidines (–)-223AB and 3-epi-(–)-223AB

The oxidative cyclization of amino alcohols by osmium tetroxide/NMO or tetrapropylammonium perruthenate (TPAP)/NMO was found to provide an N,O-acetal moiety through the trapping of the resulting iminium ion by the alcohol. These two transformations were demonstrated in the synthesis of indolizidines (–)-223AB and 3-epi-(–)-223AB.

Manganese Complexes of Pyrrole- and Indolecarboxamide Ligands: Synthesis, Structure, Electrochemistry, and Applications in Oxidative and Lewis-Acid-Assisted Catalysis

This work shows the synthesis and structural, spectroscopic, and electrochemical properties of MnIII complexes supported with pyrrole- and indolecarboxamide ligands. In all cases, the respective ligand constitutes a N4 coordination sphere about the MnIII ion. The MnIII complexes of pyrrolecarboxamide ligands are square pyramidal with a fifth Cl atom, whereas analogous complexes of indolecarboxamide ligands are essentially square planar. Electrochemical studies reveal highly negative MnIII/II and moderately positive MnIV/III redox potentials. In situ generated Mn4+ species of the pyrrolecarboxamide ligands were characterized by absorption and electron paramagnetic resonance spectroscopy. All complexes functioned as catalysts in olefin epoxidation reactions by using PhIO as the oxo-transfer agent. All complexes also acted as Lewis acid catalysts for ring-opening reactions of assorted epoxides with various nucleophiles. We also show a one-pot, two-step epoxidation reaction followed by ring opening, which illustrates the catalytic significance of the present complexes. Importantly, MnIII complexes carrying electron-donating substituents on the ligand were found to be better catalysts.