154472-05-6

Basic information

• Product Name: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol
• Synonyms: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol
• CAS NO: 154472-05-6
• Molecular Weight: 205.3
• Mol File: 154472-05-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol(154472-05-6)
• EPA Substance Registry System: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol(154472-05-6)

Safety Data

• Hazardous Substances Data: 154472-05-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 20780-54-5 (S)-styrene oxide 
• 875-74-1 (R)-phenylglycine 
• 111-24-0 1,5-dibromo-pentane 
• 56613-80-0 D-2-phenylglycinol 
• 126366-28-7 (2-hydroxy-1-phenylethyl)pyridinium chloride 
• 584-08-7 potassium carbonate 

Downstream Products

• 155796-94-4 (αR)-N-(2-hydroxy-1-phenylethyl)piperidine-2-one 
• 135286-01-0 (S)-2-phenyl-2-(piperidin-1-yl)ethanol 
• 54985-88-5 (+)-stenusine 
• 850350-07-1 (2'R,2''S,3R)-(-)-2'-[3-(2'-methylbutyl)piperidin-1-yl]-2'-phenylethanol 
• 155797-01-6 (1'R,2''S,3R)-(-)-1-(2'-hydroxy-1'-phenylethyl)-3-(2''-methylbutyl)piperidin-2-one 
• 148054-65-3 (S)-(+)-1-(2-amino-2-phenylethyl)piperidine 
• 67031-68-9 (S)-1-phenyl-2-(piperidin-1-yl)ethyl benzoate 

Relevant articles and documents

Green Regio- and Enantioselective Aminolysis Catalyzed by Graphite and Graphene Oxide under Solvent-Free Conditions

The ring-opening reactions of epoxides with amines were efficiently and regioselectively catalyzed by high-surface-area graphite and graphene oxide under metal-free and solvent-free conditions. For epoxides without aryl groups, catalytic activity was observed only for graphene oxide, and hence, the activity must have been due to its acidic groups. For styrene oxide, instead, graphite and graphene oxide exhibited rather similar catalytic activities, and hence, the activity was mainly due to activation of the electrophilic epoxide by π-stacking interactions with the graphitic π system. The described aminolysis procedure is green and cheap because the catalyst can be recovered and recycled without loss of efficiency. Moreover, these heterogeneous catalysts exert high stereoselective control in the presence of nonracemic epoxides and provide chiral β-amino alcohols with enantiomeric excess values up to 99 %.

Dehydrogenation of cyclic tertiary amines with neighbouring of enantiomeric nucleophiles

For stereochemical investigation of their dehydrogenation, the enantiomers of the aminoalcohols 1, 2, and 3 were prepared from optically active sources, while the enantiomers of the diamines 8 and 9 were available by resolution of the racemates. The pure antipodes of 1, 2, and 3 reacted with mercury(II)-EDTA by a twofold dehydrogenation via intermediate participation of the neighbouring alcoholic group to the optically active lactams 5, 6, and 7 under complete retention of configuration. In the same manner the diamines 8 and 9 generated by four electron withdrawal the cycloamidines 10 and 11.

Hydroxamic acid anesthetic compounds

A compound of the following formula: STR1 and its pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alkenyl, C1-4 alk