150009-58-8Relevant articles and documents
Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation
Barnes, Natalie G.,Nyandoro, Kudakwashe,Jin, Hanzhang,Macmillan, Derek
, p. 1006 - 1009 (2021)
Head-to-sidechain macrocylic peptides, and neoglycopeptides, were readily prepared by site-specific amidation of aspartic and glutamic acid sidechain hydrazides. Hydrazides, serving as latent thioesters, were introduced through regioselective opening of the corresponding Nα-Fmoc protected anhydride precursors.
Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
-
, (2008/06/13)
Oligomeric compounds comprising a plurality of aminodiol monomer subunits joined by linking groups are provided, as well as libraries of such compounds and processes for preparing the oligomeric compounds and libraries.
Ready protease-catalyzed synthesis of carbohydrate-amino acid conjugates.
Boyer,Stanchev,Fairbanks,Davis
, p. 1908 - 1909 (2007/10/03)
The protease-catalyzed synthesis of amino acid est-carbohydrate conjugates as glycopeptide analogues has been achieved in a highly regioselective and carbohydrate-specific manner using amino acid vinyl ester acyl donors and minimally or completely unprotected carbohydrate acyl acceptors, which together probed active sites of proteases to reveal yield efficiencies that are modulated by the carbohydrate C-2 substitutent, and that may be exploited to allow selective one-pot syntheses.