1638497-22-9Relevant articles and documents
A kind of avanafil impurity D and synthesis method and application thereof
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Paragraph 0017; 0022, (2022/01/12)
The present invention provides a new aphranarfil impurity and synthesis method thereof, by synthesizing and characterizing the impurity, the structure of the impurity is determined, the drug impurity profile of avanafil is perfected, the resulting product is of high purity, can be used as a control for drug quality control research.
A arab league cuts down that non-intermediate the refined purification method
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Paragraph 0033-0070, (2019/04/02)
The invention provides a non-intermediate arab league cuts down that the refined purification method, it mainly utilizes arab league cuts down that non-intermediate 4 - [(3 - chloro - 4 - methoxyphenyl) methylamino] - 2 - [(S)- 2 - hydroxy methyl pyrrole
Method for preparing avanafil raw material medicine
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Paragraph 0047; 0066; 0067; 0068, (2017/08/28)
The invention relates to the technical field of medicine synthesis, and discloses a method for preparing an avanafil raw material medicine. The method comprises the following steps: taking a midbody -MI as an initial raw material, and performing an oxidation reaction, a condensation reaction with L-proline, a hydrolysis reaction and a dehydration condensation reaction in sequence, thereby obtaining avanafil. Aiming at the problems that a monitoring and analysis method of a conventional avanafil preparation method is not available, the invention provides a set of effective monitoring and detection method, the quality of middle products and final products can be effectively controlled, meanwhile due to adjusted purification methods of different steps, the purity of the middle products and the final products can be at a relatively high level, and the method is particularly applicable to industrial large-scale production.