330785-99-4 Usage
Description
5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester is a chemical compound that belongs to the class of pyrimidine carboxylates. It is an Avanafil related substance, which is a phosphodiesterase (PDE5) inhibitor. 5-Pyrimidinecarboxylic acid,
4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl
ester is characterized by its unique molecular structure, which includes a pyrimidine ring, a chloro-methoxyphenyl group, and an ethyl ester functional group. Its chemical properties and interactions with biological systems make it a potential candidate for various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester is used as a PDE5 inhibitor for the treatment of erectile dysfunction. As an Avanafil related substance, it plays a crucial role in enhancing blood flow to the penis, thereby facilitating and maintaining an erection. 5-Pyrimidinecarboxylic acid,
4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl
ester is particularly useful for patients suffering from erectile dysfunction, as it offers a potential therapeutic option to improve their sexual health and overall quality of life.
Used in Research and Development:
In addition to its pharmaceutical applications, 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester can also be utilized in research and development for the discovery of new drugs and therapies. Its unique molecular structure and biological activity make it an interesting compound for studying the mechanisms of PDE5 inhibition and its potential effects on various physiological processes. This knowledge can be applied to develop novel therapeutic strategies for treating a range of conditions, including cardiovascular diseases, neurological disorders, and other conditions related to blood flow regulation.
Used in Drug Delivery Systems:
Similar to Gallotannin, 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester can be incorporated into drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound can be effectively transported to target tissues, enhancing its efficacy and reducing potential side effects. This approach can be particularly useful in developing targeted drug delivery systems for treating specific conditions, such as erectile dysfunction or other PDE5-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 330785-99-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,0,7,8 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 330785-99:
(8*3)+(7*3)+(6*0)+(5*7)+(4*8)+(3*5)+(2*9)+(1*9)=154
154 % 10 = 4
So 330785-99-4 is a valid CAS Registry Number.
330785-99-4Relevant articles and documents
A arab league cuts down that non-intermediate the refined purification method
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Paragraph 0033-0070, (2019/04/02)
The invention provides a non-intermediate arab league cuts down that the refined purification method, it mainly utilizes arab league cuts down that non-intermediate 4 - [(3 - chloro - 4 - methoxyphenyl) methylamino] - 2 - [(S)- 2 - hydroxy methyl pyrrole
The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor
Sakamoto, Toshiaki,Koga, Yuichi,Hikota, Masataka,Matsuki, Kenji,Murakami, Michino,Kikkawa, Kohei,Fujishige, Kotomi,Kotera, Jun,Omori, Kenji,Morimoto, Hiroshi,Yamada, Koichiro
, p. 5460 - 5465 (2015/01/08)
Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30 = 2.1 nM) and a high isozyme selectivity.
Aromatic nitrogen-containing 6-membered cyclic compounds
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, (2008/06/13)
An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, —NH—Q—R3 (R3 is a substituted or unsubstituted nitrogen containing heterocyclic group, and Q is a lower alkylene group or a single bond), or —NH—R4 (R4 is a substituted or unsubstituted cycloalkyl group); R2 is a substituted or unsubstituted aryl group; one of Y and Z is ═CH—, and the other is ═N—, or a pharmaceutically acceptable salt thereof, these compounds exhibiting excellent selective PDE V inhibitory activities, and hence, being useful in the prophylaxis or treatment of penile erectile dysfunction, etc.
