1699-59-8

Basic information

• Product Name: 3,4-DIBENZYLOXYBENZYL CHLORIDE
• Synonyms: 4-(Chloromethyl)-1,2-bis(phenylmethoxy)benzene;3,4-Dibenzyloxybenzyl chloride,99%;3,4-DIBENZYLOXYBENZYL CHLORIDE;3,5-bis(benzyloxy)-alpha-chlorotoluene;3,4-DIBENZYLOXYBENZYL CHLORIDE 99%;3,4-Bis(benzyloxy)benzyl chloride
• CAS NO: 1699-59-8
• Molecular Formula: C₂₁H₁₉ClO₂
• Molecular Weight: 338.83
• EINECS: 216-927-0
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 1699-59-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 41-43 °C(lit.)
• Boiling Point: 455.07°C (rough estimate)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.0887 (rough estimate)
• Vapor Pressure: 5.91E-09mmHg at 25°C
• Refractive Index: 1.5330 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-DIBENZYLOXYBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIBENZYLOXYBENZYL CHLORIDE(1699-59-8)
• EPA Substance Registry System: 3,4-DIBENZYLOXYBENZYL CHLORIDE(1699-59-8)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1699-59-8(Hazardous Substances Data)

Usage

Description

3,4-Dibenzyloxybenzyl chloride is an organic compound that appears as an almost white to light beige powder. It is characterized by its chemical structure, which includes a central benzene ring with two benzyloxy groups attached at the 3 and 4 positions, and a chlorine atom attached to the benzyl group.

Uses

Used in Pharmaceutical Industry:
3,4-Dibenzyloxybenzyl chloride is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block in the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 3,4-Dibenzyloxybenzyl chloride is used as a precursor for the preparation of benzylnitrile, which is an essential compound in the synthesis of amidines. Amidines are important in the development of various chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Due to its unique chemical properties and structure, 3,4-Dibenzyloxybenzyl chloride is also utilized in research and development for the exploration of new chemical reactions and the creation of novel compounds with potential applications in various industries, such as materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C21H19ClO2/c22-14-19-11-12-20(23-15-17-7-3-1-4-8-17)21(13-19)24-16-18-9-5-2-6-10-18/h1-13H,14-16H2

Upstream product

• 100-39-0 benzyl bromide 
• 882427-72-7 3,4-(bisbenzyloxy)benzoic acid benzyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1699-58-7 3,4-bis(benzyloxy)benzyl alcohol 

Downstream Products

• 113756-42-6 8-benzyloxy-N-benzoyl-1-(3',4'-dibenzyloxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 
• 82071-47-4 1-(3,4-dibenzyloxyphenylmethyl)-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine 
• 121102-14-5 N-<3,4-bis(benzyloxy)benzyl>ethylenediamine 
• 1699-60-1 (3,4-bis-benzyloxyphenyl)acetonitrile 
• 77564-63-7 2-Benzyl-5,7-bis-benzyloxy-1-(3,4-bis-benzyloxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline 
• 178415-79-7 (2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(3,4-dibenzyloxybenzyl)pyrrolidine-2,4-dicarboxylate 
• 78178-78-6 2-(3',4'-dibenzyloxyphenacyl)-N-(3'',4''-dibenzyloxyphenylacetyl)pyrrolidine 
• 78178-81-1 6,7-di-(3',4'-dibenzyloxyphenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizine 
• 78178-88-8 6,7-di(3,4-dibenzyloxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine 
• 78178-82-2 7-(4-Benzyloxy-3-methoxy-phenyl)-6-(3,4-bis-benzyloxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one 
• 78178-89-9 7-(4-Benzyloxy-3-methoxy-phenyl)-6-(3,4-bis-benzyloxy-phenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 78178-79-7 1-(4-Benzyloxy-3-methoxy-phenyl)-2-{1-[2-(3,4-bis-benzyloxy-phenyl)-acetyl]-pyrrolidin-2-yl}-ethanone 
• 78278-42-9 (+/-)-6-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine 

Relevant articles and documents

Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.

CAFFEINATED COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES

Compounds and their pharmaceutically acceptable salts for treatment of Beta-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease