1703-23-7

Basic information

• Product Name: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone
• Synonyms: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone
• CAS NO: 1703-23-7
• Molecular Formula: C₈H₁₂Cl₂N₂O₂
• Molecular Weight: 239.1
• Mol File: 1703-23-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 428.3°Cat760mmHg
• Flash Point: 212.8°C
• Appearance: /
• Density: 1.375g/cm³
• Vapor Pressure: 1.54E-07mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone(1703-23-7)
• EPA Substance Registry System: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone(1703-23-7)

Safety Data

• Hazardous Substances Data: 1703-23-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12Cl2N2O2/c9-5-7(13)11-1-2-12(4-3-11)8(14)6-10/h1-6H2

Upstream product

• 110-85-0 piperazine 
• 79-04-9 chloroacetyl chloride 
• 6091-62-9 piperazine dihydrochloride hydrate 

Downstream Products

• 92897-32-0 2H,5H,-6,7-dihydrothiazolo<3,2-a>pyrimidin-3(2H)-one 
• 443735-96-4 C₂₈H₂₆N₂O₄ 
• 97848-35-6 N,N'-di(m-acetamidophenoxy)acetylpiperazine 
• 97848-34-5 N,N'-diacetylpiperazine 
• 133270-11-8 C₄₅H₅₇N₉O₆ 
• 97848-33-4 N,N'-di(o-acetamidophenoxy)acetylpiperazine 
• 134268-74-9 2-(2'-Hydroxy-biphenyl-2-yloxy)-1-{4-[2-(2'-hydroxy-biphenyl-2-yloxy)-acetyl]-piperazin-1-yl}-ethanone 
• 1009-85-4 1,4-bis-(2-chloro-ethyl)-piperazine 

Relevant articles and documents

A new quinoline-based chemosensor in ratiometric sensing of Hg2+ ions

A new quinoline-based chemosensor 1 has been designed and synthesised. Its metal ion-binding properties have been documented in organic and aqueous organic solvents. While chemosensor 1 recognises Hg2+ ions (Ka = 2.15 × 104 M-1) by exhibiting ratiometric change in emission in CHCl3/CH3OH (1:1, v/v), under similar condition both Zn2+ and Cd2+ ions are sensed by significant non-ratiometric increase in emission with measurable red shift. In DMSO/H2O (5:95, v/v), the sensor 1 exhibits a greater selectivity towards Hg2+ ions (Ka = 9.20 × 103 M -1) over the other metal ions examined.

A benzimidazolium-based new flexible cleft built on the piperazine unit: A case of selective fluorometric sensing of ATP

A benzimidazole-based compound 1 built on the piperazine motif has been designed and synthesized. The chemosensor 1 is highly selective and sensitive towards ATP over ADP and AMP in CH3CN/H2O (1:1, v/v, using 10 mM HEPES buffer, pH 6.4) as evidenced by the significant change in emission. Furthermore, sensor 1 is cell permeable and can detect the presence of ATP in Human cervical cancer cells (HeLa). This journal is

Synthesis of N-Heterocyclic Carbine Silver(I) and Palladium(II) Complexes with Acylated Piperazine Linker and Catalytic Activity in Three Types of C—C Coupling Reactions

Two bis-imidazolium salts LH2·Cl2 and LH2·(PF6)2 with acylated piperazine linker and two N-heterocyclic carbene (NHC) silver(I) and palladium(II) complexes [L2Ag2](PF6)2 (1) and [L2Pd2Cl4] (2) were prepared. The crystal structures of LH2·Cl2 and 1 were confirmed by X-ray analysis. In 1, one 26-membered macrometallocycle was generated through two silver(I) ions and two bidentate ligands L. The catalytic activity of 2 was investigated in Sonogashira, Heck-Mizoroki and Suzuki-Miyaura reactions. The results displayed that these C—C coupling reactions can be smoothly carried out under the catalysis of 2.

Bi-(2-amidoacetyl)-piperazine amides derivative lubricant additive and preparation method thereof

The invention discloses a novel green multifunctional bi-(2-amidoacetyl)-piperazine amides derivative lubricant additive and a preparation method thereof. The preparation method specifically comprises the following steps: under the action of alkaline, firstly executing the amidation to piperazine and chloroacetyl chloride so as to obtain bi-(chloracetyl)-piperazine amide, and executing the nucleophilic substitution with corresponding amine to obtain a target compound as shown in the formula I. The preparation method is simple, the technological conditions are moderate, the raw materials are easily obtained, the synthesis cost is low, and the yield is high. The novel nitrogen-enriched bi-(2-amidoacetyl)-piperazine amides derivative can be exclusively used as a multifunctional additive of lubricating oil, or compounded to be used as the additive of other lubricating oil. The novel green multifunctional bi-(2-amidoacetyl)-piperazine amides derivative lubricant additive can be used for the general working conditions and the high-temperature working condition environment, is capable of remarkably improving the extreme pressure wear-resistant antifriction property of base oil and effectively improving the corrosion resistance of the base oil, and is a green biodegradable multifunctional lubricant additive.