17046-84-3 Usage
Description
1,4-Ditosylpiperazine is a chemical compound that features a piperazine ring with two tosyl (or toluenesulfonyl) groups attached at the 1 and 4 positions. It is recognized for its strong nucleophilic reactivity, which is instrumental in the formation of carbon-carbon and carbon-nitrogen bonds. 1,4-Ditosylpiperazine serves as a versatile intermediate in the synthesis of pharmaceuticals and other organic compounds, and it has been explored for its potential as a precursor in the development of new drug candidates, showing promise in addressing various diseases and medical conditions.
Uses
Used in Pharmaceutical Synthesis:
1,4-Ditosylpiperazine is used as a versatile intermediate for the synthesis of pharmaceuticals, leveraging its strong nucleophilic reactivity to facilitate the formation of essential carbon-carbon and carbon-nitrogen bonds in the creation of complex molecules with specific biological activities.
Used in Organic Chemistry:
In the field of organic chemistry, 1,4-Ditosylpiperazine is employed as a reagent in the preparation of various heterocyclic compounds, contributing to the development of novel chemical entities with potential applications in different industries.
Used in Drug Development:
1,4-Ditosylpiperazine has been investigated for its potential as a precursor in the development of new drug candidates, indicating its utility in the advancement of treatments for a range of diseases and medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 17046-84-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,4 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17046-84:
(7*1)+(6*7)+(5*0)+(4*4)+(3*6)+(2*8)+(1*4)=103
103 % 10 = 3
So 17046-84-3 is a valid CAS Registry Number.
17046-84-3Relevant articles and documents
Aryl(sulfonyl)amino group: A convenient and stable yet activated modification of amino group for its intramolecular displacement
Kato, Yuzo,Yen, Dinh Hoang,Fukudome, Yasuhiro,Hata, Takeshi,Urabe, Hirokazu
supporting information; experimental part, p. 4137 - 4139 (2010/11/04)
Aryl(sulfonyl)amino groups, readily derived from sulfonyl- or arylamines by standard methods as well as the recently introduced methods of sulfonylation and arylation, proved to be good leaving groups in intramolecular substitution reactions by various nitrogen, oxygen, and carbon nucleophiles.
Microwave-assisted synthesis of 1,4,7,10-tetraazacyclododecane
Jebasingh,Alexander
, p. 653 - 657 (2007/10/03)
Tosylated cyclen is synthesized by the condensation of tritosylated diethanolamine and tosylamide monosodium salt under microwave irradiation, which, on detosylation with HBr, gives cyclen dihydrobromide. X-ray crystal structure of cyclen dihydrobromide i
N-(ω-TOSYLOXYALKYL)PHTHALIMIDES AS REACTIVE GENERAL SYNTHONS FOR INTRODUCING ALKYLAMINO GROUPS AND THEIR APPLICATION FOR THE "SELF-PROLIFERATIVE" SYNTHESIS OF OPEN-CHAIN POLYAMINES
Iwata, Masaaki,Kuzuhara, Hiroyoshi
, p. 369 - 372 (2007/10/02)
New synthetic routes to N-(ω-tosyloxyalkyl)phthalimides (2) were developed and the synthetic utility of 2 as alkylating reagents was exemplified in the open-chain polyamine synthesis involving the "self-proliferative" process.
