25770-53-0

Basic information

• Product Name: Benzenesulfonamide, N-[(dimethylamino)methylene]-4-methyl-
• Synonyms: N-[(dimethylamino)methylidene]-4-methylbenzenesulfonamide;HMS2532K07;Benzenesulfonamide,N-[(dimethylamino)methylene]-4-methyl;N-p-tosyl-N',N'-dimethylformamidine;N1,N1-dimethyl-N2-4-tolylsulfonylformamidine;Benzenesulfonamide, N-[(dimethylamino)methylene]-4-methyl-;N-tosyl-N',N'-dimethylformamidine;N,N-dimethyl-N'-tosylformimidamide;N,N-dimethyl-N'-p-tolylsulfonylformamidine
• CAS NO: 25770-53-0
• Molecular Formula: C10H14N2O2S
• Molecular Weight: 226.299
• Mol File: 25770-53-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 135-137 °C(Solv: ethanol (64-17-5))
• Boiling Point: 343.8±35.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzenesulfonamide, N-[(dimethylamino)methylene]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(dimethylamino)methylene]-4-methyl-(25770-53-0)
• EPA Substance Registry System: Benzenesulfonamide, N-[(dimethylamino)methylene]-4-methyl-(25770-53-0)

Safety Data

• Hazardous Substances Data: 25770-53-0(Hazardous Substances Data)

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 68-12-2 N,N-dimethyl-formamide 
• 941-55-9 4-toluenesulfonyl azide 
• 18856-68-3 diethyl N,N-dimethylaminomethylenemalonate 
• 207804-83-9 N-acryloyl-N-methyl-N'-p-tolylsulfonylurea 
• 98-59-9 p-toluenesulfonyl chloride 
• 3695-00-9 di(4-tosyl)amine 
• 121-44-8 triethylamine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 75391-97-8 4-methyl-N-(pyridin-2-ylmethyl)benzenesulfonamide 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 1423-60-5 methyl ethynyl ketone 
• 598-56-1 N,N-dimethyl-ethanamine 
• 33840-97-0 (toluene-4-sulfonyl)-imidosulfurous acid dichloride 

Downstream Products

• 147189-48-8 3-<4-(methylphenyl)sulfonylaminomethylene>-1,1,7,7-tetramethoxy-4-heptanone 

Relevant articles and documents

Visible-light enabled room-temperature dealkylative imidation of secondary and tertiary amines promoted by aerobic ruthenium catalysis

Employing sulfonyl azide as a nitrogen donor, a visible-light-enabled aerobic dealkylative imidation of tertiary and secondary amines involving C(sp3)-C(sp3) bond cleavage with moderate to excellent yields at room temperature is described. It has been demonstrated that this imidation could take place spontaneously upon visible-light irradiation, and could be facilitated considerably by a ruthenium photocatalyst and oxygen. An alternative mechanism to the previous aerobic photoredox pathway has also been proposed.

The C=C Bond Decomposition Initiated by Enamine-Azide Cycloaddition for Catalyst- and Additive-Free Synthesis of N-Sulfonyl Amidines

The chemo-selective synthesis of N-sulfonyl amidines is realized via the decomposition of the enamine C=C bond of enaminoesters through an in situ generated triazoline intermediate. Control experiments prove that the electron withdrawing ester group in the enamine component is crucial in inducing the chemo-selective formation of amidines. The method is featured with high efficiency and sustainability by employing pure water as medium without requiring any catalyst or additive.

N -Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N -sulfonyl amidines

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.