260391-64-8

Basic information

• Product Name: ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone)
• Synonyms: ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone)
• CAS NO: 260391-64-8
• Molecular Weight: 632.624
• Mol File: 260391-64-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone)(CAS DataBase Reference)
• NIST Chemistry Reference: ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone)(260391-64-8)
• EPA Substance Registry System: ((propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone)(260391-64-8)

Safety Data

• Hazardous Substances Data: 260391-64-8(Hazardous Substances Data)

Upstream product

• 140658-45-3 1',3'-bis(4-carboxy-2-methoxy-5-nitrophenoxy)propane 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 260391-66-0 C₄₅H₅₀N₆O₁₆ 
• 260391-65-9 (2-Amino-4-{3-[5-amino-4-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methoxy-phenoxy]-propoxy}-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone 

Relevant articles and documents

PYRROLOBENZODIAZEPINE CONJUGATES

A compound of formula (I) and salts and solvates thereof, wherein RL is a linker for connection to a cell binding agent, which is formula (IIa) wherein Q is a tripeptide residue of formula (A), where x is 1 or 2, -C(=O)-Qx-NH- is a dipeptide residue; X is: formula (B), where a = 0 to 5, b = 0 to 16, c = 0 or 1, d = 0 to 5; and GL is a linker for connecting to a Ligand Unit.

Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT

Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.