2609-49-6Relevant articles and documents
Novel chiral bis-dipolar 6,6'-disubstituted binaphthol derivatives for second-order nonlinear optics: Synthesis and linear and nonlinear optical properties
Deussen,Hendrickx,Boutton,Krog,Clays,Bechgaard,Persoons,Bj?rnholm
, p. 6841 - 6852 (1996)
A number of thermally and optically stable, bis-dipolar chiral molecules based on two geometries of the binaphthol (BN) system with different acceptors/substituents have been synthesized for the first time, and the synthetic routes are reported: optically
From polynorbornene to the complementary polynorbornene by replication
Lin, Nai-Ti,Lin, Shu-Yi,Lee, Shern-Long,Chen, Chun-Hsien,Hsu, Chao-Hsiung,Hwang, Lian Pin,Xie, Zhen-Yu,Chen, Chung-Hsuan,Huang, Shou-Ling,Luh, Tien-Yau
, p. 4481 - 4485 (2007)
In undergoing a DNA-like replication process, the single-stranded polynorbornene acts as a template for norbornene monomer adhesion through ester linkages (see scheme). Polymerization of the adhered monomers affords the corresponding unsymmetric double-st
Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine
Hosseini-Sarvari, Mona,Koohgard, Mehdi
, p. 5905 - 5911 (2021/07/12)
In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.
Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study
Wang, Ruifeng,Zhao, Xiangxin,Yu, Sijia,Chen, Yixuan,Cui, Hengxian,Wu, Tianxiao,Hao, Chenzhou,Zhao, Dongmei,Cheng, Maosheng
, (2020/07/23)
Focal adhesion kinase (FAK) is an intracellular non-receptor tyrosine kinase responsible for development of various tumor types. Aiming to explore new potent inhibitors, two series of 2,4-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives were designed and synthesized on the base of structure-based design strategy. Biological evaluation indicated that most of these new compounds could potently inhibit FAK kinase, leading to the promising inhibitors against the proliferation of U-87MG, A-549, and MDA-MB-231 cancer cell lines. Among them, the optimized compound 18h potently inhibited the enzyme (IC50 = 19.1 nM) and displayed stronger potency than TAE-226 in U-87MG, A-549 and MDA-MB-231 cells, with IC50 values of 0.35, 0.24, and 0.34 μM, respectively. Compound 18h is a multi-target kinase inhibitor. Furthermore, compound 18h also exhibited relatively less cytotoxicity (IC50 = 3.72 μM) toward a normal human cell line, HK2. According to the flow cytometry and wound healing assay results, compound 18h effectively induced apoptosis and G0/G1 phase arrest of MDA-MB-231 cells and suppressed the migration of U-87MG, A-549 and MDA-MB-231 cells. The docking study of compound 18h was performed to elucidate its possible binding modes and to provide a structural basis for the further structural guidance design of FAK inhibitors. Collectively, these data support the further development of compound 18h as a lead compound for FAK-targeted anticancer drug discovery.