29706-84-1Relevant articles and documents
Method for synthesizing zidovudine azide intermediate based on continuous flow micro-reaction technology
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Paragraph 0057-0086, (2021/10/05)
The method comprises the following steps: (1) mixing a zidovudine oxygen bridge, a nitriding reagent and a solvent, dissolving a zidovudine oxygen bridge and a azide reagent in the solvent to prepare a reaction raw material solution. (2) The reaction raw material solution is fed into a microchannel reactor for reaction to obtain a product solution containing a zidovudine azide intermediate. By adopting the micro-channel reactor as the core reaction equipment, continuous nitriding reaction can be carried out, the dosage of the nitriding reagent is reduced, the reaction rate is accelerated, and the reaction risk is reduced.
Serendipitous discovery of a zidovudine guanidine complex: A superior process for the production of zidovudine
Radatus, Bruno K.
, p. 1281 - 1286 (2012/01/13)
A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.
An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds
Sirion, Uthaiwan,Kim, Hee Jun,Lee, Jae Hak,Seo, Jai Woong,Lee, Byoung Se,Lee, Sang Ju,Oh, Seung Jun,Chi, Dae Yoon
, p. 3953 - 3957 (2008/02/04)
The Cu(I)-catalyzed, 1,3-dipolar cycloaddition reaction was applied successfully to the synthesis of small, F-18-labeled biomolecules, and an optimal condition was developed for one-pot, two-step reaction without any interim purifications. This technique was employed in various F-18-labeled, 1,2,3-triazole syntheses with high radiochemical yield.