31271-90-6

Basic information

• Product Name: N-(P-TOLUENESULFONYL)INDOLE
• Synonyms: 1-tosylindole;N-Tosylindole;N-Ts-indole;1-[(4-Methylphenyl)sulfonyl]-1H-indole
• CAS NO: 31271-90-6
• Molecular Formula: C₁₅H₁₃NO₂S
• Molecular Weight: 271.07
• Mol File: 31271-90-6.mol
• Article Data: 123

Chemical Properties

• Melting Point: 84-86°C
• Boiling Point: 458.269 °C at 760 mmHg
• Flash Point: 230.953 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: N-(P-TOLUENESULFONYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(P-TOLUENESULFONYL)INDOLE(31271-90-6)
• EPA Substance Registry System: N-(P-TOLUENESULFONYL)INDOLE(31271-90-6)

Safety Data

• Hazardous Substances Data: 31271-90-6(Hazardous Substances Data)

Usage

Description

N-(P-TOLUENESULFONYL)INDOLE, also known as 1-(p-toluenesulfonyl)indole, is a chemical compound that serves as a stable equivalent of 4-mercaptoindoles. It is characterized by its ability to mimic the properties of 4-mercaptoindoles while offering enhanced stability, making it a valuable component in various applications.

Uses

Used in Pharmaceutical Industry:
N-(P-TOLUENESULFONYL)INDOLE is used as an intermediate in the synthesis of drugs and tablets for its ability to provide stable equivalents of 4-mercaptoindoles. This allows for the development of medications with improved stability and efficacy, ultimately benefiting patients and the healthcare industry as a whole.

InChI:InChI=1/C15H13NO2S/c1-12-6-8-14(9-7-12)19(17,18)16-11-10-13-4-2-3-5-15(13)16/h2-11H,1H3

Upstream product

• 120-72-9 indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 30765-95-8 N-p-toluenesulfonyl-2-vinylaniline 
• 136787-89-8 N-tosyl-2-(1-isopropylthio-2-methoxyethyl)anilide 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 128080-58-0 1-p-Toluenesulfonyl-2-nitropyrrole 
• 930111-84-5 3-nitro-1-(p-toluenesulfonyl)pyrrole 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 527686-25-5 4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide 
• 2232-08-8 N-tosylimidazole 
• 39830-55-2 1-[(4-methylphenyl)sulfonyl]indoline 
• 3185-99-7 Methyl p-tolyl sulfone 
• 136787-88-7 N-tosyl-2-<2-acetoxy-1-(isopropylthio)ethyl>anilide 

Downstream Products

• 114906-90-0 (E)-1-(1-tosyl-1H-indol-3-yl)but-2-en-1-one 
• 125031-67-6 2-(3,6-Diisopropyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 125031-63-2 3-(3,6-Diisopropyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 90481-77-9 3-bromo-1-(4-methylbenzenesulfonyl)-1H-indole 
• 120-72-9 indole 
• 1027031-36-2 4,4-dimethoxy-1-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-cyclohexa-2,5-dienol 
• 881406-30-0 1-(4-methylphenylsulfonyl)-1H-indole-3-sulfonyl chloride 
• 22394-27-0 1-(p-toluenesulfonyloxy)-3-oxo-2,3-dihydroindole 

Relevant articles and documents

Electrophilic fluorination in the synthesis of new fluoroindoles

Fluorination of trialkylstannylindoles with caesium fluoroxysulfate on Selectfluor(TM) was investigated for the synthesis of inter-alia 2- and 3- fluoroindoles. Caesium fluoroxysulfate gave good yields of these potentially useful intermediates. Selectfluo

Silaphenylmercuric triflate catalyzed reactions: Synthesis of a solid-supported mercuric salt catalyst

Let it flow, let it flow: A procedure to generate the first solid-supported mercuric salt, silaphenylmercuric triflate, is described. Silaphenylmercuric triflate showed remarkable catalytic activity for an indole synthesis, furanoyne cyclization, arylyne

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Ester-substituted indoline and preparation method thereof

The invention provides ester-substituted indoline and a preparation method thereof. The ester-substituted indoline is an indoline compound substituted by different ester groups. Indole is prepared into an epoxy dihydroindole compound, so that the activity