34161-81-4

Basic information

• Product Name: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid
• Synonyms: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid
• CAS NO: 34161-81-4
• Molecular Weight: 305.354
• Mol File: 34161-81-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(34161-81-4)
• EPA Substance Registry System: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(34161-81-4)

Safety Data

• Hazardous Substances Data: 34161-81-4(Hazardous Substances Data)

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 1426922-36-2 N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 99-04-7 m-Toluic acid 

Downstream Products

• 34161-85-8 N-(2-formyl-4-methylphenyl)-4-methylbenzenesulfonamide 
• 132354-03-1 (E)-N-<2-(2-methylsulphinyl-2-methylthiovinyl)-4-methylphenyl>toluene-4-sulphonamide 
• 132353-95-8 N-Allyl-N-[2-(1-chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-4-methyl-benzenesulfonamide 
• 132354-04-2 methyl N-(2-methylthiocarbonylmethyl-4-methylphenyl)-N-(toluene-4-sulphonyl)-2-aminoacetate 
• 132353-94-7 [[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 
• 28561-54-8 2-Benzoyl-4-methyl-N-(p-toluolsulfonyl)-anilid 
• 1315477-41-8 1-(5-methyl-2-(tosylamino)phenyl)-1-phenylprop-2-yn-1-ol 
• 1315477-58-7 5-methyl-3-phenyl-1-tosyl-1H-indole-2-carbaldehyde 
• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 

Relevant articles and documents

Late-Stage Amination of Drug-Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium-Catalyzed C?H Activation

The functionalization of C?H bonds, ubiquitous in drugs and drug-like molecules, represents an important synthetic strategy with the potential to streamline the drug-discovery process. Late-stage aromatic C?N bond–forming reactions are highly desirable, but despite their significance, accessing aminated analogues through direct and selective amination of C?H bonds remains a challenging goal. The method presented herein enables the amination of a wide array of benzoic acids with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug-like molecules. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug-delivery conjugates, PROTACs, and probes for chemical biology. This rapid access to valuable analogues, combined with operational simplicity and applicability to high-throughput experimentation has the potential to aid and considerably accelerate drug discovery.

Method for Preparing Derivatives of Anthranilic acid and Anti-inflammatory Use Thereof

The present invention relates to a production method of anthranilic acid derivatives which reacts benzoic acid derivatives and phenylsulfonyl azide derivatives under the presence of a [IrCp*Cl_2]_2 catalyst; and relates to an anti-inflammatory use of the

Metal-free synthesis of 1H-indole-2-carbaldehydes by N-iodosuccinimide- mediated cyclization of 1-(2′-anilinyl)prop-2-yn-1-ols in water. A formal synthesis of (R)-calindol

A N-iodosuccinimide (NIS)-mediated method to prepare 1H-indole-2- carbaldehydes efficiently from cycloisomerization of 1-(2-aminophenyl)prop-2-yn- 1-ols is described. The reaction is operationally straightforward and accomplished in good to excellent yiel