51908-64-6

Basic information

• Product Name: 4-Chloro-1-butyne
• Synonyms: 4-Chloro-1-butyne;4-chlorobut-1-yne
• CAS NO: 51908-64-6
• Molecular Formula: C₄H₅Cl
• Molecular Weight: 88.54
• Mol File: 51908-64-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 96 ºC
• Flash Point: 8 ºC
• Appearance: /
• Density: 0.986
• Vapor Pressure: 49.6mmHg at 25°C
• Refractive Index: 1.4376-1.4420
• CAS DataBase Reference: 4-Chloro-1-butyne(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1-butyne(51908-64-6)
• EPA Substance Registry System: 4-Chloro-1-butyne(51908-64-6)

Safety Data

• Hazard Codes: T,Xn
• Statements: 25-43-41-22
• Safety Statements: 45-36/37/39-26
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 51908-64-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-1-butyne, also known as 4-chlorobut-1-yne or 4-chloro-but-1-yne, is a chemical compound with the molecular formula C4H5Cl. It is a clear, colorless liquid with a pungent odor, and it is classified as an alkyne due to the presence of a carbon-carbon triple bond. 4-Chloro-1-butyne is primarily used as an intermediate in the synthesis of other chemicals, such as pharmaceuticals, agrochemicals, and dyes. It is also used in research and laboratory settings as a reagent for chemical reactions. The compound is considered to be hazardous and should be handled and stored with appropriate safety measures.

InChI:InChI=1/C4H5Cl/c1-2-3-4-5/h1H,3-4H2

Upstream product

• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 927-74-2 3-Butyn-1-ol 

Downstream Products

• 14396-90-8 N-(3-butynyl)phthalimide 

Relevant articles and documents

Facile Synthesis of 2-Aminocyclobutenylphosphonates

The addition of various amines to diethyl 4-chlorobut-1-yn-1-ylphosphonate produced novel biologically potent substituted diethyl 2-aminocyclobut-1-en-1-ylphosphonates in 70–83% isolated yield. This regioselective reaction was carried out at room temperat

Synthesis of the ortho / meta / para isomers of relevant pharmaceutical compounds by coupling a Sonogashira reaction with a regioselective hydration

Aryl ketones substituted in ortho, meta, and para position are prepared by a palladium-catalyzed Sonogashira reaction followed by a regioselective hydration of the so-formed alkyne with triflimidic acid or a gold catalyst, under catalytic conditions. This methodology opens a way to obtain substituted aryl alkyl ketones from readily available starting materials, haloarenes, and terminal alkynes. The syntheses of the different regioisomers of haloperidol, melperone, pipamperone, and ibuprofen are presented. Structure-activity relationships for these compounds are studied with dopaminergic and cyclooxigenase binding assays.

Copper-catalyzed asymmetric 1,4-addition of alkenyl alanes to N-substituted-2-3-dehydro-4-piperidones

Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.