927-74-2 Usage
Description
3-Butyn-1-ol is a terminal acetylenic compound that is but-1-yne with one of the methyl hydrogens substituted by a hydroxy group. It is a colorless liquid with specific enthalpies of combustion and vaporization that can be measured by static bomb combustion calorimetry and correlation gas chromatography techniques.
Uses
Used in Chemical Synthesis:
3-Butyn-1-ol is used as an alkynyl substrate in the study of palladium-catalyzed coupling with beta-tetrionic acid bromide, leading to the formation of alkynyl substituted furanones in good yield.
Used in Pharmaceutical Industry:
3-Butyn-1-ol serves as an intermediate for the synthesis of active pharmaceutical ingredients, such as fexofenadine, which is an antihistamine drug used for treating allergy symptoms.
Used in Organic Chemistry:
3-Butyn-1-ol is utilized for the preparation of Markovnikov addition products, which are important in various organic reactions and synthesis processes.
Used in the Synthesis of Oxygen-Containing Heterocycles:
3-Butyn-1-ol acts as a synthon for the preparation of oxygen-containing heterocycles, which are valuable compounds in the field of organic chemistry and have potential applications in various industries.
Used in the Preparation of Protected Esters:
3-Butyn-1-ol is also used in the synthesis of protected esters of S-Hydroxy-L-isoleucine, which are important building blocks in the development of pharmaceuticals and other bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 927-74-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,2 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 927-74:
(5*9)+(4*2)+(3*7)+(2*7)+(1*4)=92
92 % 10 = 2
So 927-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O/c1-2-3-4-5/h1,5H,3-4H2
927-74-2Relevant articles and documents
Vanadium-Catalyzed Oxidative Debenzylation of O-Benzyl Ethers at ppm Level
Urgoitia, Garazi,SanMartin, Raul,Herrero, María Teresa,Domínguez, Esther
, p. 3307 - 3312 (2016/10/21)
An advantageous methodology for the oxidative debenzylation of ethers has been developed. Very low amounts of a catalyst system based on vanadyl acetylacetonate and a triazole type pincer ligand allow the selective oxidative cleavage of a number of O-benzyl ethers in the presence of oxygen as the sole oxidant. The methodology tolerates a number of functional groups such as halo-, alkoxy-, or trifluoromethylarenes, alkyne, alkene, ether, and acetal units. Large-scale deprotections can be also carried out by the optimized procedure, which is amenable to enantioenriched reactants as well. (Figure presented.).
Zinc triflate: A mild and efficient catalyst for deprotection of tetrahydropyranyl ethers
Srinivasulu,Satyanarayana,Ravi Kumar
, p. 2419 - 2422 (2014/03/21)
Treatment of tetrahydropyranyl (THP) ethers with zinc triflate in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols are obtained in excellent yields.
Chemoselective TBS deprotection of primary alcohols by means of pyridinium tribromide (Py·Br3) in MeOH
Martinez-Solorio, Dionicio,Jennings, Michael P.
, p. 5175 - 5178 (2008/12/20)
A catalytic amount of pyridinium tribromide (Py·Br3) in MeOH chemoselectively deprotects primary TBS ethers in the presence of a variety of other protecting and common functional groups in modest to excellent yields when performed at 0 °C.