538-71-6 Usage
Description
Domiphen bromide, also known as Domiphen, is a quaternary ammonium compound and cationic surfactant with potent antimicrobial properties. It is effective against a range of bacteria, including A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes, as well as inhibiting the growth and spore germination of C. neoformans yeast. Additionally, it has the ability to inhibit the human-ether-a-go-go-related gene (hERG) channel, making it a versatile compound with various applications across different industries.
Uses
Used in Synthetic Chemistry:
Domiphen bromide is used as a phase transfer catalyst, facilitating reactions in synthetic chemistry by promoting the transfer of reactants between different phases, thus enhancing the efficiency and yield of chemical processes.
Used in Industrial Applications:
As a cationic surfactant with antimicrobial properties, Domiphen bromide is utilized in various industrial applications, such as in the formulation of antiseptics, disinfectants, and biocides. Its broad-spectrum activity against bacteria and yeast makes it a valuable component in maintaining cleanliness and preventing the spread of microorganisms in industrial settings.
Used in Agricultural Applications:
In agriculture, Domiphen bromide is employed as a biocide to control the growth of harmful microorganisms that can negatively impact crop yields and quality. Its antimicrobial activity helps protect plants from diseases and pests, contributing to a more sustainable and efficient agricultural system.
Used in Veterinary Applications:
Domiphen bromide is also used in the veterinary industry as an antiseptic and disinfectant, helping to maintain hygiene and prevent the spread of infections in animals. Its effectiveness against a wide range of bacteria and yeast makes it a valuable tool in ensuring the health and well-being of animals in veterinary care.
Used in Clinical Applications:
In the clinical setting, Domiphen bromide is used as an active pharmaceutical ingredient, leveraging its antimicrobial properties to treat various infections. Its ability to inhibit the hERG channel also makes it a potential candidate for further research and development in the pharmaceutical industry, with the potential to contribute to the treatment of various medical conditions.
Originator
Bradosol,Ciba,US,1958
Manufacturing Process
7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling
water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization
from acetone, melts at 112°C. It is a white crystalline powder which dissolves
easily in water to give a neutral reaction.
Safety Profile
Poison by intraperitoneal
and intravenous routes. hfutauon data reported.
When heated to decomposiuon it emits very toxic
fumes of NOx, NH3, and Br-. See also
BROMIDES.
Check Digit Verification of cas no
The CAS Registry Mumber 538-71-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 538-71:
(5*5)+(4*3)+(3*8)+(2*7)+(1*1)=76
76 % 10 = 6
So 538-71-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1
538-71-6Relevant articles and documents
Dentifrice containing a poly(hydroxypropyl ether) non-ionic surfactant and a specified cationic polymer
-
, (2008/06/13)
Dentifrice containing, in combination, (A) a poly(hydroxypropyl ether) nonionic surfactant, and (B) a cationic polymer selected from the group consisting of (i) a vinylpyrrolidone/dialkylaminoalkyl or -hydroxyalkyl acrylate or methacrylate, quaternized or nonquaternized and (ii) a cationic polysaccharide. This dentifrice is characterized by good foamability, pleasant taste and it does not attack the buccal mucosae and the gums.
