54921-72-1Relevant articles and documents
Bisphosphonate prodrugs: Synthesis of new aromatic and aliphatic 1-hydroxy-1,1-bisphosphonate partial esters
Monteil, Maelle,Guenin, Erwann,Migianu, Evelyne,Lutomski, Didier,Lecouvey, Marc
, p. 7528 - 7537 (2007/10/03)
Methods for the preparation of various 1-hydroxy-1,1-bisphosphonate partial esters were developed. They were obtained from (alkyl or phenyl) bis(trimethylsilyl) phosphite and aromatic or aliphatic acid chlorides, followed by methanolysis.
Studies on aryl H-phosphonates. 3. Mechanistic investigations related to the disproportionation of diphenyl H-phosphonate under anhydrous basic conditions
Kers, Annika,Kers, Inger,Stawinski, Jacek,Sobkowski, Michal,Kraszewski, Adam
, p. 9931 - 9944 (2007/10/03)
Diphenyl H-phosphonate undergoes under anhydrous reaction conditions a base-promoted disproportionation to triphenyl phosphite and phenyl H- phosphonate. On the basis of 31P NMR data the most likely mechanism for this transformation was proposed. In order to substantiate these findings and to get a deeper insight into the chemistry of aryl H-phosphonate esters, we carried out also some studies on activation of phenyl and diphenyl H- phosphonates with various condensing agents. We found that aryl vs alkyl esters of phosphonic acid often follow different reaction pathways during the activation, and this can most likely be traced back to higher electrophilicity of the phosphorus centre and to higher reactivity of the P- H bonds in aryl H-phosphonate derivatives.
Bis Phosphite, a New Reagent for Synthesizing Mono- and Diesters of Phosphorous Acid
Gibbs, Don E.,Larsen, Catherine
, p. 410 - 413 (2007/10/02)
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