670-83-7Relevant articles and documents
Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists
Elliott, Richard L.,Oliver, Robert M.,LaFlamme, Janet A.,Gillaspy, Melissa L.,Hammond, Marlys,Hank, Richard F.,Maurer, Tristan S.,Baker, Demetria L.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.
, p. 3593 - 3596 (2003)
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding models, but were also found to have undesired behavioral effects in spontaneous locomotor activity.
Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C–C Coupling and C?N Condensation Cascade Reactions
Fang, Shengyang,Yu, Haihua,Yang, Xicheng,Li, Jianqi,Shao, Liming
supporting information, p. 3312 - 3317 (2019/06/13)
A convenient Ni(II)-catalyzed C?C and C?N cascade coupling reaction was developed to directly access various 2,4-disubstituted imidazoles. The reaction scope covers a variety of aryl and aliphatic substitutions, which demonstrate moderate-to-excellent yie
Rh-Catalyzed Annulation of ortho-C?H Bonds of 2-Arylimidazoles with 1,4,2-Dioxazol-5-ones toward 5-Arylimidazo[1,2-c]quinazolines
Wu, Xiaopeng,Sun, Song,Xu, Shengbo,Cheng, Jiang
supporting information, p. 1111 - 1115 (2018/01/27)
A Rh-catalyzed unique and direct approach for constructing a series of 5-arylimidazo[1,2-c]quinazolines in moderate to excellent yields from simple and readily available 2-arylimidazoles and 3-phenyl-1,4,2-dioxazol-5-ones was described. This procedure pro