686-50-0 Usage
Description
H-LEU-GLY-OH, also known as L-leucylglycine, is a dipeptide formed from L-leucine and glycine residues. It is characterized by its crystalline chemical properties. This dipeptide plays a significant role in biological processes, particularly in inhibiting the ubiquitin-mediated proteolysis.
Uses
Used in Pharmaceutical Applications:
H-LEU-GLY-OH is used as an inhibitor for ubiquitin-mediated proteolysis, a process that is essential for the regulation of various cellular functions, including protein homeostasis and signal transduction. By inhibiting this process, H-LEU-GLY-OH can potentially be utilized in the development of therapeutic strategies for diseases associated with abnormal protein degradation.
Used in Research and Development:
In the field of research and development, H-LEU-GLY-OH serves as a valuable compound for studying the mechanisms of protein degradation and the role of ubiquitin in cellular processes. This dipeptide can be used to develop new drugs or therapies targeting specific pathways involved in protein homeostasis and signal transduction.
Used in Drug Delivery Systems:
Similar to gallotannin, H-LEU-GLY-OH can also be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the delivery, efficacy, and targeting of H-LEU-GLY-OH can be improved, making it a more effective compound for treating specific conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 686-50-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,8 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 686-50:
(5*6)+(4*8)+(3*6)+(2*5)+(1*0)=90
90 % 10 = 0
So 686-50-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H16N2O3/c1-5(2)3-6(9)8(13)10-4-7(11)12/h5-6H,3-4,9H2,1-2H3,(H,10,13)(H,11,12)/t6-/m0/s1
686-50-0Relevant articles and documents
Letsinger,Kornet
, p. 3045 (1963)
Stereoselective ring contraction of 2,5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds
Coursindel, Thibault,Restouin, Audrey,Dewynter, Georges,Martinez, Jean,Collette, Yves,Parrot, Isabelle
experimental part, p. 210 - 217 (2010/10/01)
Ring contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate anti-proliferative activity on breast cancer cells.
N-carbamoyl derivatives and their nitrosation by gaseous NOx - A new, promising tool in stepwise peptide synthesis
Lagrille, Olivier,Taillades, Jacques,Boiteau, Laurent,Commeyras, Auguste
, p. 1026 - 1032 (2007/10/03)
New uses of the N-carbamoyl group in peptide synthesis as an Nα-protecting group in classical peptide coupling methods, and as a preactivating group for stepwise coupling by NCA formation - are presented. In the first application, the N-carbamoyldipeptide esters C-Val-Gly-OEt, C-Leu-Gly-OEt, C-Ala-Gly-OEt, and C-Ala-Phe-OEt were obtained in good yields by treatment of the corresponding N-carbamoylamino acids (CAA) with amino acid esters. Quantitative N-deprotection without racemisation was then achieved in the solid through nitrosation by gaseous NOx. The extent of racemisation occurring in the coupling step is discussed. In the second application, an easy route to amino acid N-carboxy anhydrides (NCAs) through nitrosation of CAA under the same conditions as above allowed straightforward "one-pot" peptide stepwise coupling, as demonstrated by the formation of Leu-Gly and Val-Gly in good yields and enantiomeric excess. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Presence of a dipeptidyl aminopeptidase III in Saccharomyces cerevisiae
Watanabe,Kumagai,Fujimoto
, p. 246 - 248 (2007/10/02)
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