72047-94-0 Usage
Description
2-(Trimethylsilylmethyl)allyl acetate, also known as 2-[(Acetoxymethyl)allyl]trimethylsilane, is a clear colorless liquid with a boiling point of 68-70°C at 6.5 mmHg and 60-61°C at 2.5 mmHg. It is a chemical compound that features a trimethylsilylmethyl group attached to an allyl acetate moiety, which contributes to its unique chemical properties and reactivity.
Uses
Used in Chemical Synthesis:
2-(Trimethylsilylmethyl)allyl acetate is used as a reagent in the synthesis of cyclopentane derivatives through Pd(0)-catalyzed reactions with 2π acceptors. Its unique structure allows for the formation of complex molecular architectures, which are valuable in various chemical and pharmaceutical applications.
Used in Organic Chemistry:
As a precursor for palladium trimethylenemethane cycloaddition reactions, 2-(Trimethylsilylmethyl)allyl acetate plays a crucial role in the construction of complex organic molecules. This application is particularly relevant in the fields of medicinal chemistry and materials science, where the development of novel compounds with specific properties is of great interest.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, the compound's reactivity and structural features suggest potential applications in the pharmaceutical industry. It could be used as a building block for the synthesis of bioactive molecules or as an intermediate in the production of pharmaceutical compounds.
Preparation
commercially available but expensive. Several preparations of (1) or the precursor alcohol (2) have been reported. The simplest involves the direct silylation of methallyl alcohol (eq 1).
Check Digit Verification of cas no
The CAS Registry Mumber 72047-94-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,0,4 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 72047-94:
(7*7)+(6*2)+(5*0)+(4*4)+(3*7)+(2*9)+(1*4)=120
120 % 10 = 0
So 72047-94-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H18O2Si/c1-8(6-11-9(2)10)7-12(3,4)5/h1,6-7H2,2-5H3
72047-94-0Relevant articles and documents
A Short and Efficient Preparation of 2-Trimethylsilylmethyl-2-propen-1-ol
Agnel, Gilbert,Malacria, Max
, p. 687 - 688 (1989)
2-Trimethylsilylmethyl-2-propen-1-ol is efficiently prepared in 64percent overall yield starting from the cheap propargyl alcohol.
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Trost,B.M.,Renaut,P.
, p. 6668 (1982)
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Ni-Catalyzed Cross Coupling of Alkoxide-Containing Vinyl Halides with Grignard Reagents. A "One-Pot" Synthesis of 2-[(Trimethylsilyl)methyl]-2-propen-1-yl Acetate
Organ, Michael G.,Murray, Aaron P.
, p. 1523 - 1526 (2007/10/03)
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