7244-77-1

Basic information

• Product Name: P-PROPOXYNITROBENZENE
• Synonyms: P-NITROPHENYL PROPYL ETHER;P-PROPOXYNITROBENZENE;Benzene, 1-nitro-4-propoxy-;1-nitro-4-propoxybenzene;Propyl 4-nitrophenyl ether;Einecs 230-650-2
• CAS NO: 7244-77-1
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• EINECS: 230-650-2
• Mol File: 7244-77-1.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 294.29°C (estimate)
• Flash Point: 134.5 °C
• Appearance: /
• Density: 1.1791 (estimate)
• Vapor Pressure: 0.00302mmHg at 25°C
• Refractive Index: 1.5525 (estimate)
• CAS DataBase Reference: P-PROPOXYNITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: P-PROPOXYNITROBENZENE(7244-77-1)
• EPA Substance Registry System: P-PROPOXYNITROBENZENE(7244-77-1)

Safety Data

• Hazardous Substances Data: 7244-77-1(Hazardous Substances Data)

Usage

General Description

P-Propoxynitrobenzene is a chemical compound with the formula C9H9NO3. It is a nitroaryl compound that consists of a benzene ring with a nitro group and a propoxy group attached in the para position. P-propoxynitrobenzene is commonly used as an intermediate in the synthesis of other organic compounds, and it is also used as a reagent in organic chemical reactions. It is a light yellow solid that is insoluble in water but soluble in organic solvents. P-propoxynitrobenzene is considered to be hazardous and should be handled with care due to its potential health and environmental risks.

InChI:InChI=1/C9H11NO3/c1-2-7-13-9-5-3-8(4-6-9)10(11)12/h3-6H,2,7H2,1H3

Upstream product

• 71-23-8 propan-1-ol 
• 350-46-9 4-Fluoronitrobenzene 
• 29843-53-6 dimethyl(p-nitrophenyl)sulfonium perchlorate 
• 100-02-7 4-nitro-phenol 
• 106-94-5 propyl bromide 
• 6819-41-6 sodium n-propoxide 
• 100-00-5 4-chlorobenzonitrile 
• 540-54-5 1-Chloropropane 
• 824-78-2 4-nitrophenol sodium salt 
• 1568-66-7 1-allyloxy-4-nitrobenzene 
• 214360-66-4 2-(4-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 5747-23-9 2-phenyl-1,3,2-benzodioxaborole 
• 241147-96-6 2-(4-(tert-butyl)phenyl)benzo[d][1,3,2]dioxaborole 

Downstream Products

• 59731-93-0 N-Aethyl-p-propyloxyanilin 
• 1616081-59-4 {4-[(4-propoxyphenyl)-ONN-azoxy]phenoxy}acetonitrile 
• 1616081-60-7 {4-[(4-propoxyphenyl)-NNO-azoxy]phenoxy}acetonitrile 
• 1360868-05-8 C₃₇H₃₁N₃O₄ 
• 1154534-55-0 C₂₁H₁₉N₃O₃ 
• 14921-40-5 p-n-Heptyloxybenzylidene-p-n-propoxyaniline 
• 1291082-87-5 25,27-bis[N-(1-propoxy-phenyl)aminocarbonyl]methoxy-26,28-dihydroxycalix[4]arene 
• 33228-21-6 p-n-Butyl-p'-propyloxy-azobenzol 
• 50696-00-9 C₁₈H₂₂N₂O 
• 50695-98-2 C₁₇H₂₀N₂O 
• 50695-97-1 C₁₆H₁₈N₂O 
• 98771-71-2 6-Oxo-2-(4-propoxy-phenylamino)-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 98772-22-6 6-Oxo-2-(4-propoxy-phenylamino)-1,6-dihydro-pyrimidine-5-carboxylic acid 
• 2496-27-7 4-propoxy-4'-hydroxyazobenzene 

Relevant articles and documents

Inclusion complexes of a new family of non-ionic amphiphilic dendrocalix[4]arene and poorly water-soluble drugs naproxen and ibuprofen

The inclusion complexes of a new family of nonionic amphiphilic calix[4]arenes with the anti-inflammatory hydrophobic drugs naproxen (NAP) and ibuprofen (IBP) were investigated. The effects of the alkyl chain's length and the inner core of calix[4]arenes on the interaction of the two drugs with the calix[4]arenes were explored. The inclusion complexes of Amphiphiles 1a-c with NAP and IBP increased the solubility of these drugs in aqueous media. The interaction of 1a-c with the drugs in aqueous media was investigated through fluorescence, molecular modeling, and 1H-NMR analysis. TEM studies further supported the formation of inclusion complexes. The length of lipophilic alkyl chains and the intrinsic cyclic nature of cailx[4]arene derivatives 1a-c were found to have a significant impact on the solubility of NAP and IBP in pure water.

Chromogenic nitrophenolate-based substrates for light-driven hybrid P450 BM3 enzyme assay

The incorporation of a p-nitrophenoxy moiety in substrates has enabled the development of colorimetric assays to rapidly screen for O-demethylation activity of P450 enzymes. For the light-driven hybrid P450 BM3 enzymes, where a Ru(II) photosensitizer powers the enzyme upon visible light irradiation, we have investigated a family of p-nitrophenoxy derivatives as useful chromogenic substrates compatible with the light-driven approach. The validation of this assay and its adaptability to a 96-well plate format will enable the screening of the next generation of hybrid P450 BM3 enzymes towards C-H bond functionalization of non-natural substrates.

Enhanced Reactivity of Aerobic Diimide Olefin Hydrogenation with Arylboronic Compounds: An Efficient One-Pot Reduction/Oxidation Protocol

A catalyst-free and efficient method for simultaneous olefin hydrogenation and oxidation of arylboronate esters to phenols with hydrazine hydrate and molecular oxygen is presented. The process is based on the utilization of a readily available Lewis acidic arylboron compound, which evades common problems associated with the catalyst-free aerobic hydrogenation of olefins with diimide. Using an operationally simple procedure, the protocol smoothly delivers phenol derivatives and various alkanes in excellent yields with remarkable functional group compatibility. The method allows the reaction to be scaled up to 1 g of the starting materials.