734-25-8

Basic information

• Product Name: 4'-NITRO-P-TOLUENESULFONANILIDE
• Synonyms: N-(4'-NITROPHENYL)-4-METHYL-BENZENE-SULFONAMIDE;AURORA KA-982;4'-NITRO-P-TOLUENESULFONANILIDE;4-METHYL-N-(4-NITROPHENYL)BENZENESULFONAMIDE;N-(p-nitrophenyl)-p-toluenesulphonamide;4'-Nitro-p-toluenesulfonanilide95+%;N-(4-Nitrophenyl)-p-toluenesulfonamide;Benzenesulfonamide, 4-methyl-N-(4-nitrophenyl)-
• CAS NO: 734-25-8
• Molecular Formula: C₁₃H₁₂N₂O₄S
• Molecular Weight: 292.31
• EINECS: 211-994-2
• Mol File: 734-25-8.mol
• Article Data: 45

Chemical Properties

• Melting Point: 191 °C
• Boiling Point: 469.5 °C at 760 mmHg
• Flash Point: 237.7 °C
• Appearance: /
• Density: 1.414 g/cm³
• CAS DataBase Reference: 4'-NITRO-P-TOLUENESULFONANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-NITRO-P-TOLUENESULFONANILIDE(734-25-8)
• EPA Substance Registry System: 4'-NITRO-P-TOLUENESULFONANILIDE(734-25-8)

Safety Data

• Hazardous Substances Data: 734-25-8(Hazardous Substances Data)

Usage

General Description

4'-Nitro-p-toluenesulfonanilide is a chemical compound that is commonly used as an intermediate in the synthesis of dyes and pharmaceuticals. It is a yellow solid with a molecular formula C13H10N2O5S and a molecular weight of 306.3 g/mol. 4'-NITRO-P-TOLUENESULFONANILIDE is known for its striking color and is often used as a dye intermediate at industrial scale. It is also known for its antibacterial properties and is used in some pharmaceutical formulations. However, it is important to handle this compound with caution, as it is toxic if ingested or inhaled, and may cause irritation to the skin and eyes upon contact.

Upstream product

• 68-34-8 phenyl toluenesulfonamide 
• 100-01-6 4-nitro-aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 7697-37-2 nitric acid 
• 636-98-6 p-nitrobenzene iodide 
• 70-55-3 toluene-4-sulfonamide 
• 586-78-7 para-nitrophenyl bromide 
• 100-00-5 4-chlorobenzonitrile 
• 72973-25-2 N,N-dimethyl-1-(p-tolylsulfonyl)pyridin-1-ium-4-amine chloride 
• 21849-40-1 dibromamine-T 
• 24067-17-2 4-nitrophenylboronic acid 
• 62-23-7 4-nitro-benzoic acid 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 941-55-9 4-toluenesulfonyl azide 

Downstream Products

• 121234-40-0 1,5-bis-[4-nitro-N-(toluene-4-sulfonyl)-anilino]-pentane 
• 68-34-8 phenyl toluenesulfonamide 
• 15873-51-5 4-nitroaniline hydrochloride 
• 6380-08-1 N-(4-aminophenyl)-4-methylbenzenesulfonamide 
• 19044-84-9 N-(2,4-dinitrophenyl)-4-methylbenzenesulfonamide 
• 106596-12-7 N-(4-nitro-phenyl)-N-(toluene-4-sulfonyl)-glycine 
• 111271-79-5 N-(4-nitrophenyl)-di(p-toluenesulfonyl)amine 
• 101113-21-7 toluene-4-sulfonic acid-(N-ethyl-4-nitro-anilide) 
• 6380-16-1 toluene-4-sulfonic acid-(N-methyl-4-nitro-anilide) 
• 100-01-6 4-nitro-aniline 
• 25186-43-0 N-isopropyl-p-nitroaniline 
• 104-15-4 toluene-4-sulfonic acid 
• 22019-64-3 toluene-4-sulfonic acid-(N-benzyl-4-nitro-anilide) 
• 184163-59-5 N-(2-Bromo-5-isopropyl-4-nitrophenyl)-4-methylbenzenesulphonamide 

Relevant articles and documents

Copper-mediated regioselective efficient direct ortho-nitration of anilide derivatives

The mild and readily available Cu(NO3)2 mediated ortho nitration of anilides with broad substrate using K2S2O8 as an oxidant in the absence of any other metal catalyst and nitrating agent under mild conditions was reported for the first time.

KCC-1 aminopropyl-functionalized supported on iron oxide magnetic nanoparticles as a novel magnetic nanocatalyst for the green and efficient synthesis of sulfonamide derivatives

A new magnetic nanocatalyst (Fe3O4@KCC-1-npr-NH2) was synthesized directly through the reaction of Fe3O4@KCC-1 with (3-aminopropyl) triethoxysilane (APTES) using a hydrothermal protocol. Prepared nanocomposite was used as a magnetically reusable nanocatalyst for an efficient synthesis of a broad range of sulfonamide derivatives in water as a green solvent at room temperature and the products are collected by filtration with excellent yields (85–97%). The nanocatalyst could be remarkably recovered and reused after ten times without any significant decrease in activity. This mild and simple synthesis method offers some advantages including short reaction time, high yield and simple work-up procedure.

A microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium

A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation. A series of pyrabactin analogues containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 3ae could enhance POD activity in response to heavy metal stress.