7473-18-9

Basic information

• Product Name: 2-ethoxynaphthalene-1,4-dione
• Synonyms: 1,4-naphthalenedione, 2-ethoxy-; 2-Methylmethoxy-1,4-naphthoquinone
• CAS NO: 7473-18-9
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.206
• Mol File: 7473-18-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 156.9°C
• Density: 1.23g/cm³
• Vapor Pressure: 4.37E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 2-ethoxynaphthalene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxynaphthalene-1,4-dione(7473-18-9)
• EPA Substance Registry System: 2-ethoxynaphthalene-1,4-dione(7473-18-9)

Safety Data

• Hazardous Substances Data: 7473-18-9(Hazardous Substances Data)

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 64-17-5 ethanol 
• 60-29-7 diethyl ether 
• 36417-25-1 2-hydroxy-1,4-naphthoquinone silver salt 
• 75-03-6 ethyl iodide 
• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 574-00-5 1,2-Dihydroxynaphthalene 
• 2065-37-4 2-bromo-1,4-naphthoquinone 
• 130-15-4 [1,4]naphthoquinone 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 87-66-1 2-hydroxyresorcinol 
• 2066-93-5 3,4-dioxo-3,4-dihydro-naphthalene-1-sulfonic acid 
• 3188-13-4 ethyl chloromethyl ether 

Downstream Products

• 59641-32-6 2-chloro-3-(ethoxy)-1,4-naphthoquinone 
• 57182-49-7 2-(p-toluidino)-1,4-naphthoquinone 
• 6628-97-3 2-(phenylamino)naphthoquinone 
• 21720-68-3 2-(phenylamino)-4-(phenylimino)-1(4H)-naphthalenone 
• 94015-53-9 atovaquone 

Relevant articles and documents

Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives

A series of 1,4-naphthoquinone derivatives of lawsone (1), 6-hydroxy-1,4-naphthoquinone (2), and juglone (3) were synthesized by alkylation, acylation, and sulfonylation reactions. The yields of lawsone derivatives 1a-1k (type A), 6-hydroxy-1,4-naphthoqui

A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26

The preparation of heteroatom-substituted p-quinones is ideally performed by direct addition of a nucleophile followed by in situ reoxidation. Albeit an appealing strategy, the reactivity of the p-quinone moiety is not easily tamed and no broadly applicable method for heteroatom functionalization exists. Shown herein is that Co(OAc)2 and Mn(OAc)3?2 H2O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S nucleophiles, using oxygen as the terminal oxidant. Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented.

Unusual, chemoselective etherification of 2-hydroxy-1,4-naphthoquinone derivatives utilizing alkoxymethyl chlorides: Scope, mechanism and application to the synthesis of biologically active natural product (±)-lantalucratin C

A novel etherification of 2-hydroxy-1,4-naphthoquinone derivatives with alkoxyalkyl chlorides and hydride bases is described. Precise study of the conditions and substrate scope suggested that the reaction occurs specifically in the molecule having a 2-hydroxy-1,4-benzoquinone skeleton. A chemoselective O-methylation reaction was achieved to afford a synthetically important intermediate, which offered easy access to a natural product possessing anti-tumor activity.