769121-30-4

Basic information

• Product Name: tert-butyl 4-(acetylamino)phenylcarbamate
• Synonyms: tert-butyl 4-(acetylamino)phenylcarbamate
• CAS NO: 769121-30-4
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.29362
• Mol File: 769121-30-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(acetylamino)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(acetylamino)phenylcarbamate(769121-30-4)
• EPA Substance Registry System: tert-butyl 4-(acetylamino)phenylcarbamate(769121-30-4)

Safety Data

• Hazardous Substances Data: 769121-30-4(Hazardous Substances Data)

Upstream product

• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 75-36-5 acetyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 105-53-3 diethyl malonate 
• 4248-19-5 tert-butyl carbazate 
• 103-88-8 4-bromoacetanilide 
• 108-24-7 acetic anhydride 
• 756483-96-2 tert-butyl 4-acetylphenylcarbamate oxime 
• 232597-42-1 tert-butyl 4-acetylphenylcarbamate 
• 106-50-3 1,4-phenylenediamine 

Downstream Products

• 122-80-5 N-acetyl-p-phenylenediamine 
• 35008-62-9 4-(N-acetylamino)phenyl isothiocyanate 
• 18144-47-3 tert-butyl 4-aminobenzoate 

Relevant articles and documents

Thiazole ring-containing amide compounds as well as preparation method and application thereof

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Direct synthesis of secondary amides from ketones through Beckmann rearrangement using O-(mesitylsulfonyl)hydroxylamine

The Beckmann rearrangement is a versatile method for the preparation of secondary amides from ketones via oxime intermediates and has been widely used in the synthesis of bioactive natural products and pharmaceuticals. Herein, we have developed a highly efficient direct method for the preparation of secondary amides and lactams from ketones using O-(mesitylsulfonyl)hydroxylamine (MSH). The reactions proceed rapidly at room temperature under mild condition without requiring any additive, and tolerate multiple functional groups. A simple aqueous work-up often furnished the products in excellent yield with high purity.

o-Phthalic Anhydride/Zn(OTf)2 co-catalyzed Beckmann rearrangement under mild conditions

o-Phthalic anhydride/Zn(OTf)2 co-catalyzed Beckmann rearrangement was developed, producing the corresponding amide in up to 99% yield with acid-sensitive functionalities tolerated well, and the scale of the reaction could be enlarged to 77 mmol and the excellent yield was maintained. A successive procedure was developed. Moreover, the reaction was carried out at rt under nearly neutral conditions, and the workup was concise. These features illustrated the potential of the protocol in amide synthesis.