78835-67-3

Basic information

• Product Name: {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester
• CAS NO: 78835-67-3
• Molecular Weight: 496.928
• Mol File: 78835-67-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester(78835-67-3)
• EPA Substance Registry System: {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester(78835-67-3)

Safety Data

• Hazardous Substances Data: 78835-67-3(Hazardous Substances Data)

Upstream product

• 54788-35-1 diethyl 1-aminoethylphosphonate 
• 55478-54-1 Z-Phe(4Cl)-OH 

Downstream Products

• 78835-68-4 {1-[2-Amino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid 

Relevant articles and documents

STUDIES ON THE SYNTHESIS OF CHEMOTHERAPEUTICS. PART XI. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF PHOSPHONOPEPTIDES

A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.