78835-68-4

Basic information

• Product Name: 4-chloro-N-(1-phosphonoethyl)phenylalaninamide
• CAS NO: 78835-68-4
• Molecular Formula: C₁₁H₁₆ClN₂O₄P
• Molecular Weight: 306.6825
• Mol File: 78835-68-4.mol
• Article Data: 1

Chemical Properties

• Density: 1.438g/cm³
• Refractive Index: 1.586
• CAS DataBase Reference: 4-chloro-N-(1-phosphonoethyl)phenylalaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(1-phosphonoethyl)phenylalaninamide(78835-68-4)
• EPA Substance Registry System: 4-chloro-N-(1-phosphonoethyl)phenylalaninamide(78835-68-4)

Safety Data

• Hazardous Substances Data: 78835-68-4(Hazardous Substances Data)

Upstream product

• 55478-54-1 Z-Phe(4Cl)-OH 
• 78835-67-3 {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester 

Relevant articles and documents

STUDIES ON THE SYNTHESIS OF CHEMOTHERAPEUTICS. PART XI. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF PHOSPHONOPEPTIDES

A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.