79757-15-6

Basic information

• Product Name: Cyclohexylidene-pyridin-4-yl-acetonitrile
• CAS NO: 79757-15-6
• Molecular Weight: 198.268
• Mol File: 79757-15-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexylidene-pyridin-4-yl-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexylidene-pyridin-4-yl-acetonitrile(79757-15-6)
• EPA Substance Registry System: Cyclohexylidene-pyridin-4-yl-acetonitrile(79757-15-6)

Safety Data

• Hazardous Substances Data: 79757-15-6(Hazardous Substances Data)

Upstream product

• 6975-71-9 1-cyclohexenylacetonitrile 
• 26156-84-3 N-tritylpyridinium tetrafluoroborate 

Relevant articles and documents

Synthetic Applications of N-N Linked Heterocycles. Part 14. The Preparation of α-(4-Pyridyl)esters and α-(4-Pyridyl)nitriles by Regiospecific Attack of Ester and Nitrile Anions on Pyridinium Salts

Reactions between N-(2,6-dimethyl-4-oxopyridin-1-yl)pyridinium tetrafluoroborate (1) and lithio-derivatives of esters and nitriles give only low yields of 1,4-dihydro-adducts (3) and (7) due apparently to competing proton abstraction from the pyridone methyl groups.This limitation with salt (1) appears only with C-H acids of pKa > 20.Decomposition of the adducts under free-radical conditions yields α-(4-pyridyl)-esters (4) and -nitriles (8) essentially quantitatively.The same pyridyl-esters and -nitriles may be prepared conveniently in good overall yields by the reaction between the appropriate lithium salts and N-triphenylmethylpyridinium salts.The scope and limitations of the method are discucced. 2-Methyl-N-triphenylmethylpyridinium tetrafluoroborate is reported for the first time.