80-39-7

Basic information

• Product Name: N-Ethyl-p-toluenesulfonamide
• Synonyms: Benzenesulfonamide, N-ethyl-4-methyl-;Ethyl toluenesulfonamide;Ethylp-toluenesulfonamide;n-ethyl-4-methyl-benzenesulfonamid;n-ethyl-4-methylbenzenesulfonamide;N-Ethyl-4-methyl-benzenesulfonamide;n-ethyl-4-toluenesulfonamide;N-Ethyl-p-methylbenzenesulfonamide
• CAS NO: 80-39-7
• Molecular Formula: C₉H₁₃NO₂S
• Molecular Weight: 199.27
• EINECS: 201-275-1
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 80-39-7.mol
• Article Data: 28

Chemical Properties

• Melting Point: 63-65 °C(lit.)
• Boiling Point: 208 °C745 mm Hg(lit.)
• Flash Point: 141.9 °C
• Appearance: off-white crystalline solid
• Density: 1.26 g/cm3
• Refractive Index: 1.5270 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.86±0.50(Predicted)
• Water Solubility: <0.01 g/100 mL at 18℃
• Stability: Stable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: N-Ethyl-p-toluenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-p-toluenesulfonamide(80-39-7)
• EPA Substance Registry System: N-Ethyl-p-toluenesulfonamide(80-39-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 80-39-7(Hazardous Substances Data)

Usage

Description

N-Ethyl-p-toluenesulfonamide is an off-white crystalline solid that is soluble in dilute alcohol or ligroin. It is a chemical compound with the molecular formula C8H11NSO2 and is known for its various applications across different industries.

Uses

Used in Dental Materials:
N-Ethyl-p-toluenesulfonamide is used as a resin carrier in dental materials for isolating cavities below restorations. Its role in dental applications is crucial for ensuring the proper setting and bonding of dental resins, contributing to the overall effectiveness and durability of dental restorations.
Used in Plasticizers:
N-Ethyl-p-toluenesulfonamide is utilized as a plasticizer in various materials such as polyvinyl alcohol lacquers, polyamides, and cellulose acetate. As a plasticizer, it helps to increase the flexibility, workability, and processability of these materials, making them more suitable for a wide range of applications.
Used in Chemical Synthesis:
N-Ethyl-p-toluenesulfonamide is employed as a reagent in the sulfonamidation of imidazopyridines. This chemical process is essential for the synthesis of various pharmaceutical compounds and organic molecules, highlighting the importance of N-Ethyl-p-toluenesulfonamide in the field of organic chemistry and drug development.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for N-Ethyl-p-toluenesulfonamide are not available; however, N-Ethyl-p-toluenesulfonamide is probably combustible.

InChI:InChI=1/C9H13NO2S/c1-3-8-6-7(2)4-5-9(8)10-13(11)12/h4-6,13H,3H2,1-2H3,(H,10,11,12)

Upstream product

• 75-04-7 ethylamine 
• 155164-58-2 2-(4-methylbenzenesulfonyl)-4,5-dichloropyridazin-3-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 349098-36-8 N-ethyl cyclohexylbenzene sulfonamide 
• 64-17-5 ethanol 
• 70-55-3 toluene-4-sulfonamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 557-66-4 ethanamine hydrochloride 
• 941-55-9 4-toluenesulfonyl azide 
• 74-85-1 ethene 
• 109-63-7 boron trifluoride diethyl etherate 
• 21567-23-7 N-ethyl-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide 
• 29981-92-8 1-tosyl-3-methyl-imidazolium chloride 
• 141-43-5 ethanolamine 

Downstream Products

• 10285-92-4 N-ethyl-N-butyl-toluene-4-sulfonamide 
• 4703-19-9 N,N-diphenyl-p-toluenesulfonamide 
• 649-15-0 N,N-diethyl-4-methylbenzenesulfonamide 
• 37477-72-8 C₁₀H₁₃ClN₂O₅S₂ 
• 56059-57-5 N-Ethyl-N-thallium(I)-4-methylphenylsulfonamid 
• 71173-13-2 N-ethyl-N-p-toluenesulfonylacetamide 
• 5228-67-1 N-Aethyl-N--formamid-diaethylacetal 
• 58754-95-3 N-(2,2-dimethoxyethyl)-p-toluenesulfonamide 
• 87010-92-2 C₉H₁₄N₂O₂S 
• 113812-28-5 N-ethyl-N-(3-chloropropyl)-p-toluenesulfonamide 
• 53839-01-3 1-<3.4-Difluorphenyl>-2-aethylaminoaethanol 
• 259656-68-3 N-[(4R)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl]-N-ethyl-p-toluenesulfonamide 
• 309974-76-3 2-dec-9-enyl-N-ethyl-4-methyl-benzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 

Relevant articles and documents

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

The chemoselective cleavage of C-N bonds of amides, sulfonamides, and acylsulfonamides by aluminum halides is described. AlCl3and AlI3display complementary reactivities toward N-alkyl and N-acyl moieties. N-Alkylacylsulfonamides, sec

Manganese-Catalyzed N-F Bond Activation for Hydroamination and Carboamination of Alkenes

A visible-light-promoted method for generating amidyl radicals from N-fluorosulfonamides via a manganese-catalyzed N-F bond activation strategy is reported. This protocol employs a simple manganese complex, Mn2(CO)10, as the precatalyst and a cheap silane, (MeO)3SiH, as both the hydrogen-atom donor and the F-atom acceptor, enabling intramolecular/intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes. A wide range of valuable aliphatic sulfonamides can be readily prepared using these practical reactions.

Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).